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Machine translation
1. (WO2003055876) CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/055876    International Application No.:    PCT/US2002/041407
Publication Date: 10.07.2003 International Filing Date: 23.12.2002
Chapter 2 Demand Filed:    09.06.2003    
IPC:
C07D 235/14 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 471/04 (2006.01), C07D 471/06 (2006.01), C07D 491/04 (2006.01)
Applicants: ANORMED INC. [CA/CA]; No. 200-20353 64th Avenue Langley, British Columbia V2Y 1N5 (CA) (For All Designated States Except US).
BRIDGER, Gary, J. [US/US]; (US) (For US Only).
SKERLJ, Renato, T. [US/CA]; (CA) (For US Only).
KALLER, Al [US/CA]; (CA) (For US Only).
HARWIG, Curtis [CA/CA]; (CA) (For US Only).
BOGUCKI, David [CA/CA]; (CA) (For US Only).
WILSON, Trevor [CA/CA]; (CA) (For US Only).
CRAWFORD, Jason [CA/CA]; (CA) (For US Only).
MCEACHERN, Ernest, J. [CA/CA]; (CA) (For US Only).
ATSMA, Bem [CA/CA]; (CA) (For US Only).
NAN, Siqiao [CN/CA]; (CA) (For US Only).
ZHOU, Yuanxi [CA/CA]; (CA) (For US Only).
SCHOLS, Dominique [BE/BE]; (BE) (For US Only).
SMITH, Christopher, Dennis [CA/CA]; (CA) (For US Only).
DI FLURI, Rosaria, Maria [CA/CA]; (CA) (For US Only)
Inventors: BRIDGER, Gary, J.; (US).
SKERLJ, Renato, T.; (CA).
KALLER, Al; (CA).
HARWIG, Curtis; (CA).
BOGUCKI, David; (CA).
WILSON, Trevor; (CA).
CRAWFORD, Jason; (CA).
MCEACHERN, Ernest, J.; (CA).
ATSMA, Bem; (CA).
NAN, Siqiao; (CA).
ZHOU, Yuanxi; (CA).
SCHOLS, Dominique; (BE).
SMITH, Christopher, Dennis; (CA).
DI FLURI, Rosaria, Maria; (CA)
Agent: MURASHIGE, Kate, H.; Morrison & Foerster LLP 3811 Valley Center Drive Suite 500 San Diego, CA 92130-2332 (US)
Priority Data:
60/342,716 21.12.2001 US
60/350,822 17.01.2002 US
Title (EN) CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
(FR) COMPOSES HETEROCYCLIQUES A EFFICACITE ACCRUE SE FIXANT SUR LES RECEPTEURS DE LA CHIMIOKINE
Abstract: front page image
(EN)The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
(FR)L'invention concerne des composés hétérocycliques constitués d'un atome d'azote central entouré par trois groupes pendants, deux de ces groupes étant de préférence du benzimidazolyl méthyle et du tétrahydroquinolyle, le troisième groupe pendant contenant N et facultativement des cycles supplémentaires. Les composés selon l'invention se fixent sur les récepteurs de la chimiokine, notamment sur les récepteurs CXCR4 et CCR5, et présentent des effets protecteurs contre l'infection de cellules cibles par le virus d'immunodéficience humaine (VIH).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)