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1. (WO2003055867) BIPHENYLMETHYL-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE AS PPAR-GAMMA ACTIVATORS

Pub. No.:    WO/2003/055867    International Application No.:    PCT/FR2002/004232
Publication Date: Jul 10, 2003 International Filing Date: Dec 9, 2002
IPC: C07D 277/34
C07D 417/12
Applicants: GALDERMA RESEARCH & DEVELOPMENT, SNC
BERNARDON, Jean-Michel
CLARY, Laurence
TERRANOVA, Eric
Inventors: BERNARDON, Jean-Michel
CLARY, Laurence
TERRANOVA, Eric
Title: BIPHENYLMETHYL-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE AS PPAR-GAMMA ACTIVATORS
Abstract:
The invention concerns bi-aromatic compounds of general formula (I), wherein: R1 is (a) or (b), R5 being hydroxy or alkoxy and R6 being alkyl, OR14 or SR14 which are PPAR-gamma receptors. They are useful in pharmaceutical compositions for use in human and veterinary medicine (in dermatology, as well as for cardiovascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.