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1. (WO2003055848) UREA DERIVATIVES AS VR1- ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/055848    International Application No.:    PCT/EP2002/014216
Publication Date: 10.07.2003 International Filing Date: 13.12.2002
Chapter 2 Demand Filed:    16.07.2003    
IPC:
C07C 275/24 (2006.01), C07C 275/28 (2006.01), C07C 275/30 (2006.01), C07C 275/32 (2006.01), C07C 275/40 (2006.01), C07C 275/42 (2006.01), C07C 323/43 (2006.01), C07D 209/88 (2006.01), C07D 213/40 (2006.01), C07D 213/75 (2006.01), C07D 217/06 (2006.01), C07D 231/56 (2006.01), C07D 295/135 (2006.01), C07D 307/52 (2006.01), C07D 317/06 (2006.01), C07D 317/58 (2006.01), C07D 333/20 (2006.01), C07D 333/36 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
YURA, Takeshi [JP/JP]; (JP) (For US Only).
MOGI, Muneto [JP/JP]; (JP) (For US Only).
IKEGAMI, Yuka [JP/JP]; (JP) (For US Only).
MASUDA, Tsutomu [JP/JP]; (JP) (For US Only).
KOKUBO, Toshio [JP/JP]; (JP) (For US Only).
URBAHNS, Klaus [DE/JP]; (JP) (For US Only).
YOSHIDA, Nagahiro [JP/JP]; (JP) (For US Only).
MARUMO, Makiko [JP/JP]; (JP) (For US Only).
SHIROO, Masahiro [JP/JP]; (JP) (For US Only).
TAJIMI, Masaomi [JP/JP]; (JP) (For US Only).
TAKESHITA, Keisuke [JP/JP]; (JP) (For US Only).
MORIWAKI, Toshiya [JP/JP]; (JP) (For US Only).
TSUKIMI, Yasuhiro [JP/JP]; (JP) (For US Only)
Inventors: YURA, Takeshi; (JP).
MOGI, Muneto; (JP).
IKEGAMI, Yuka; (JP).
MASUDA, Tsutomu; (JP).
KOKUBO, Toshio; (JP).
URBAHNS, Klaus; (JP).
YOSHIDA, Nagahiro; (JP).
MARUMO, Makiko; (JP).
SHIROO, Masahiro; (JP).
TAJIMI, Masaomi; (JP).
TAKESHITA, Keisuke; (JP).
MORIWAKI, Toshiya; (JP).
TSUKIMI, Yasuhiro; (JP)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
2001-395032 26.12.2001 JP
2001-395033 26.12.2001 JP
Title (EN) UREA DERIVATIVES AS VR1- ANTAGONISTS
(FR) DERIVES D'UREE
Abstract: front page image
(EN)This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R1- R6 and X have the same meanings given in the description, which is useful as an active ingredient of pharmaceutical preparations. The urea derivatives of the present invention has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.
(FR)L'invention concerne des dérivés d'urée et des sels de ceux-ci utiles en tant qu'ingrédient actif de préparations pharmaceutiques. Les dérivés d'urée de cette invention possèdent une excellente activité en tant qu'antagoniste de VR1 et sont utiles dans la prophylaxie et le traitement de maladies associées à l'activité de VR1, plus spécifiquement dans le traitement de l'incontinence urinaire insistante, hyperactivité de la vessie, douleur chronique, douleur neuropathique, douleur postopératoire, douleur arthritique rhumatoïde, névralgie, neuropathies, algésie, blessure des nerfs, ischémie, maladie neurodégénérative, accident vasculaire cérébral, incontinence et/ou troubles inflammatoires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)