Search International and National Patent Collections

1. (WO2003055507) REMEDIES FOR ANOREXIA OR LIFESTYLE-RELATED DISEASES AND METHOD OF SCREENING THE SAME

Pub. No.:    WO/2003/055507    International Application No.:    PCT/JP2002/013757
Publication Date: Jul 10, 2003 International Filing Date: Dec 27, 2002
IPC: A61K 38/16
C12N 15/11
G01N 33/50
G01N 33/566
Applicants: SUMITOMO PHARMACEUTICALS CO., LTD.

SUGARU, Eiji

YAMANAKA, Mitsugu

ICHIHARA, Junji

TAIJI, Mutsuo

Inventors: SUGARU, Eiji

YAMANAKA, Mitsugu

ICHIHARA, Junji

TAIJI, Mutsuo

Title: REMEDIES FOR ANOREXIA OR LIFESTYLE-RELATED DISEASES AND METHOD OF SCREENING THE SAME
Abstract:
It is intended to provide novel remedies for lifestyle-related diseases or remedies for anorexia whereby the amount of food ingested can be favorably controlled and a method of screening the same. More specifically, remedies for anorexia which contain as the active ingredient a substance inhibiting the expression or function of GPCR and GPRC5D expressed in the hypothalamus; remedies for lifestyle-related diseases which contain as the active ingredient a substance potentiating the expression or function of the above receptors; a screening system comprising a series of co-expression systems of GPRC5D with various G-proteins; and a method of screening a substance having a therapeutic activity on anorexia or lifestyle-related diseases by using the above-described screening system.