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1. (WO2003055490) 4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS

Pub. No.:    WO/2003/055490    International Application No.:    PCT/EP2002/013530
Publication Date: Jul 10, 2003 International Filing Date: Nov 29, 2002
IPC: C07D 239/84
Applicants: MERCK PATENT GMBH
GERICKE, Rolf
BEIER, Norbert
WILM, Claudia
Inventors: GERICKE, Rolf
BEIER, Norbert
WILM, Claudia
Title: 4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS
Abstract:
The invention relates to compounds of formula (I), where Ar = phenyl or naphthyl substituted by X and additionally substituted by R3 and R4, Y = (A), (B) or (C), X = H, NR6R7 or a saturated 5-7 membered ring with two N atoms, R1, R2, R3, R4 independently = H, A, OA, Hal, CF3, OH, NO2, NH2, NHA, NA2, NH-CO-A, NH-CO-Ph, SA, SO-A, SO2-A, SO2-Ph, CN, OCF3, CO-A, CO2H, CO2A, CO-NH2, CO-NHA, CO-NA2, SO2NH2, SO2NHA, SO2NA2 or unsubstituted or mono- or poly-substituted phenyl with A, OA, Hal or CF3, the salts, solvates and use thereof as NHE-3 inhibitors.