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1. (WO2003055477) METHOD FOR THE TREATMENT OF MC RECEPTOR RELATED DISORDERS WITH A CHELATE AND/OR A CHELATOR

Pub. No.:    WO/2003/055477    International Application No.:    PCT/DK2002/000902
Publication Date: Jul 10, 2003 International Filing Date: Dec 20, 2002
IPC: A61K 31/33
A61K 31/4427
Applicants: 7TM PHARMA A/S
LANGE, Birgitte, Holst
SCHWARTZ, Thue, W.
Inventors: LANGE, Birgitte, Holst
SCHWARTZ, Thue, W.
Title: METHOD FOR THE TREATMENT OF MC RECEPTOR RELATED DISORDERS WITH A CHELATE AND/OR A CHELATOR
Abstract:
The present invention relates to a method for reducing overweight and/or treating and/or preventing overweight, obesity and/or complications to obesity (e.g. diabetes type 2, hypertension, hypercholesterolemia, hypertriglyceridemia, cardiovascular diseases and/or orarthritic diseases). The method comprises administering to an animal such as, e.g. a human and/or domestic animal need thereof an effective amount of a chelate and/or a chelator which is capable of binding or otherwise interacting with a natural metal-ion binding site in an MC receptor (melanocortin receptor) from an MC-R family. The invention also relates to methods for treating and/or preventing diabetes mellitus type II ,conditions involving the immune system, inflammation, male or female sexual dysfunctions including erectile dysfunction, anorexia and other appetite disorders, steroidal disorders and perspiration disorders. Furthermore, the invention relates to a cosmetic method for reducing overweight, to the use of a chelate and/or a chelator for the preparation of a pharmaceutical composition and to the use of a chelate and/or chelator as a lead compound in a drug discovery process for identifying ligands that ineract with an MC receptor. The example compounds of the invention are heterocyclic compounds, e.g. bipyridine derivatives.