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Machine translation
1. (WO2003054155) PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/054155    International Application No.:    PCT/US2002/040235
Publication Date: 03.07.2003 International Filing Date: 16.12.2002
Chapter 2 Demand Filed:    19.07.2003    
IPC:
C12N 9/02 (2006.01), C12Q 1/26 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P. O. Box 4000, Route 206 and Provinceline Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
GOLDBERG, Steven, L. [US/US]; (US) (For US Only).
CINO, Paul, M. [US/US]; (US) (For US Only).
PATEL, Ramesh, N. [US/US]; (US) (For US Only).
NANDURI, Venkata, B. [US/US]; (US) (For US Only).
JOHNSTON, Robert, M. [US/US]; (US) (For US Only)
Inventors: GOLDBERG, Steven, L.; (US).
CINO, Paul, M.; (US).
PATEL, Ramesh, N.; (US).
NANDURI, Venkata, B.; (US).
JOHNSTON, Robert, M.; (US)
Agent: SHER, Audrey; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/341,933 19.12.2001 US
60/375,530 25.04.2002 US
Title (EN) PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
(FR) PICHIA PASTORIS FORMATE DESHYDROGENASE ET SES UTILISATIONS
Abstract: front page image
(EN)This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.
(FR)L'invention concerne une enzyme Pichia pastoris formate déshydrogénase (FDH) de recombinaison qui catalyse l'oxydation de la formate en dioxyde de carbone et la réduction simultanée de la nicotinamide adénine dinucléotide (NAD+) vers sa forme réduite (NADH). L'invention concerne également des acides nucléiques isolés codant des polypeptides P. pastoris FDH, leurs fragments et variants, ainsi que des vecteurs et des cellules hôtes comprenant ces acides nucléiques. Elle concerne aussi des polypeptides P. pastoris FDH de recombinaison, des fragments et variants de ceux-ci, et des anticorps qui se lient spécifiquement à ces polypeptides, aux fragments ou aux variants. L'invention concerne enfin des procédés permettant d'obtenir des acides nucléiques P. pastoris FDH, des polypeptides, et des anticorps, ainsi que des procédés d'utilisation de P. pastoris FDH dans diverses réactions dans des applications industrielles ou pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)