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1. (WO2003054018) ANTI-TIRC7 ANTIBODIES IN THERAPY OF INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/054018    International Application No.:    PCT/EP2002/014733
Publication Date: 03.07.2003 International Filing Date: 23.12.2002
Chapter 2 Demand Filed:    21.07.2003    
IPC:
A61K 39/395 (2006.01), C07K 16/28 (2006.01)
Applicants: GENPAT77 PHARMACOGENETICS AG [DE/DE]; Robert-Koch-Platz 4, Luisencarree, 10115 Berlin (DE) (For All Designated States Except US).
UTKU, Nalan [DE/DE]; (DE) (For US Only)
Inventors: UTKU, Nalan; (DE)
Agent: MÜLLER FOTTNER STEINECKE; Rechtsanwälte Patentanwälte, Postfach 31 01 40, 80102 München (DE)
Priority Data:
01130730.3 21.12.2001 EP
02013261.9 17.06.2002 EP
02018809.0 22.08.2002 EP
Title (EN) ANTI-TIRC7 ANTIBODIES IN THERAPY OF INFLAMMATORY DISEASES
(FR) ANTICORPS ANTI-TIRC7 SERVANT AU TRAITEMENT DE MALADIES INFLAMMATOIRES
Abstract: front page image
(EN)A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises particular therapeutic and preventive treatment regimens for the administration of a T-cell immune response cDNA 7 (TIRC7) antagonist, preferably an anti-TIRC7 antibody. Particularly useful monoclonal, in particular chimeric anti-TIRC7 antibodies are described. Furthermore, a combination therapy for the treatment of an inflammatory disease, particularly rheumatoid arthritis, is provided involving the use of TIRC7 antagonist, such as anti-TIRC7 antibody in conjunction with an anti-inflammatory drug such as TNF-α antagonist
(FR)Cette invention porte sur une méthode de traitement de troubles inflammatoires et en particulier de l'arthrite. Cette méthode comprend des régimes de traitement préventifs et thérapeutiques particuliers pour l'administration d'un antagoniste de l'ADNc 7 à réponse immunitaire spécifique aux lymphocytes T (TIRC7), de préférence d'un anticorps anti-TIRC7. Cette invention concerne également des anticorps anti-TIRC7 monoclonaux, en particulier chimériques, particulièrement utiles. En outre, cette invention concerne une polythérapie servant au traitement d'une maladie inflammatoire, en particulier de la polyarthrite rhumatoïde, et faisant appel à un antagoniste du TIRC7, tel qu'un anticorps anti-TIRC7, utilisé conjointement à un anti-inflammatoire tel qu'un antagoniste du facteur TNF-α.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)