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1. (WO2003054010) EARLY STAGE REDOX-RELATED APOPTOSIS MODULATOR-2 (ESRAM-2)

Pub. No.:    WO/2003/054010    International Application No.:    PCT/GB2002/005785
Publication Date: Jul 3, 2003 International Filing Date: Dec 19, 2002
IPC: A61K 38/00
C07K 14/47
Applicants: EIRX THERAPEUTICS LIMITED
HAYES, Ian
COTTER, Thomas
MURPHY, Finbarr
SEERY, Liam
Inventors: HAYES, Ian
COTTER, Thomas
MURPHY, Finbarr
SEERY, Liam
Title: EARLY STAGE REDOX-RELATED APOPTOSIS MODULATOR-2 (ESRAM-2)
Abstract:
The invention provides a polypeptide ESRAM-2 and a nucleic acid encoding said polypeptide. The invention further provides a method for detecting apoptosis in a cell comprising detecting an alteration in any one of: i) an ESRAM-2 polypeptide having an amino acid sequence as set out in SEQ ID NO: 1; ii) a polypeptide having at least 80 % homology with i); iii) a nucleic acid encoding a polypeptide having the sequence set out in i) or ii); iv) a nucleic acid which hybridises under stringent conditions to the sequence set out in iii); or v) the complement of iii) or iv). The invention accordingly provides a method of modulating apoptosis by modulating ESRAM-2 gene expression and a method for identifying genes associated with ESRAM-2 gene expression and thus identifying other genes associated with apoptosis. The invention also provides a novel nucleic acid sequence encoding the promoter region for ESRAM-2.