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1. WO2003053942 - ARYLOXYPHENYL AND ARYLSULFANYLPHENYL DERIVATIVES

Publication Number WO/2003/053942
Publication Date 03.07.2003
International Application No. PCT/DK2002/000859
International Filing Date 16.12.2002
Chapter 2 Demand Filed 24.06.2003
IPC
A61K 31/495 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C07D 295/15 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
14substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
145with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
15to an acyclic saturated chain
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 295/15
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
14substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
145with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
15to an acyclic saturated chain
Applicants
  • H. LUNDBECK A/S [DK]/[DK] (AllExceptUS)
  • SMITH, Garrick, Paul [GB]/[DK] (UsOnly)
  • MIKKELSEN, Gitte [DK]/[DK] (UsOnly)
  • ANDERSEN, Kim [DK]/[US] (UsOnly)
  • GREVE, Daniel [DK]/[DK] (UsOnly)
  • RUHLAND, Thomas [DE]/[DK] (UsOnly)
  • WREN, Stephen, P. [GB]/[GB] (UsOnly)
Inventors
  • SMITH, Garrick, Paul
  • MIKKELSEN, Gitte
  • ANDERSEN, Kim
  • GREVE, Daniel
  • RUHLAND, Thomas
  • WREN, Stephen, P.
Priority Data
60/342,65320.12.2001US
PA 2001 0192720.12.2001DK
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ARYLOXYPHENYL AND ARYLSULFANYLPHENYL DERIVATIVES
(FR) DERIVES D'ARYLOXYPHENYLE ET D'ARYLSULFANYLPHENYLE
Abstract
(EN) The invention provides compounds of the formula (I) wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.
(FR) Cette invention concerne des composés représentés par la formule (I) dont les substituants sont comme définis dans le descriptif. Ces composés sont de précieux inhibiteurs de transport de glycine.
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