WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2003053405) METHOD AND COMPOSITION FOR DRY EYE TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/053405    International Application No.:    PCT/IL2001/001015
Publication Date: 03.07.2003 International Filing Date: 01.11.2001
Chapter 2 Demand Filed:    08.12.2002    
IPC:
A61K 9/00 (2006.01), A61K 31/436 (2006.01), A61K 38/13 (2006.01)
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM [IL/IL]; 46 Jabotinsky Street, 92182 Jerusalem (IL) (For All Designated States Except US).
NOVAGALI PHARMA SA [FR/FR]; Bâtiment Genavenir IV, 1 rue Pierre Fontaine, F-91000 Evry (FR) (For All Designated States Except US).
BENITA, Simon [IL/IL]; (IL) (For US Only).
LAMBERT, Gregory [BE/FR]; (FR) (For US Only)
Inventors: BENITA, Simon; (IL).
LAMBERT, Gregory; (FR)
Agent: REINHOLD COHN AND PARTNERS; P.O. Box 4060, 61040 Tel Aviv (IL)
Priority Data:
Title (EN) METHOD AND COMPOSITION FOR DRY EYE TREATMENT
(FR) PROCEDE ET COMPOSITION POUR LE TRAITEMENT DE L'OEIL SEC
Abstract: front page image
(EN)A method and composition for treating a dry eye condition by topically applying to the eye surfaces an emulsion forming a tear film that acts to lubricate the eye and to inhibit evaporation therefrom. The emulsion is constituted by water in which is dispersed a mixture that includes a phospholipid, a non-polar oil, a non-toxic emulsifying agent and a polar lipid that imparts a net positive charge to the film that is distributed throughout the film, causing the film to be electrostatically attracted to the anionic surface of the eye whereby the film adheres thereto and cannot be washed away. Includable in the mixture is a non-soluble therapeutic agent, such as cyclosporin which is effective against an eye disease and is delivered to the eye by the film.
(FR)L'invention concerne un procédé et une composition pour le traitement de l'oeil sec. Il s'agit d'administrer localement à la surface de l'oeil une émulsion formant un film lacrymal qui lubrifie l'oeil et qui inhibe l'évaporation depuis l'oeil. L'émulsion considérée est constituée d'eau renfermant une dispersion de mélange qui comprend un phospholipide, une huile non polaire, un émulsifiant non toxique et un lipide polaire conférant au film une charge positive nette répartie sur tout le film, et induisant une attraction électrostatique du film vis-à-vis de la surface anionique de l'oeil. En conséquence, le film adhère à la surface de l'oeil et ne peut pas être éliminé par rinçage. Le mélange décrit peut également renfermer un agent thérapeutique non soluble, du type cyclosporine, qui a une action préventive efficace contre une maladie des yeux et que le film lui-même fournit à l'oeil.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)