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1. (WO2003053367) HYDROGENATION OF PRECURSORS TO THIAZOLIDINEDIONE ANTIHYPERGLYCEMICS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/053367    International Application No.:    PCT/US2002/041278
Publication Date: 03.07.2003 International Filing Date: 20.12.2002
Chapter 2 Demand Filed:    21.07.2003    
IPC:
C07D 277/20 (2006.01), C07D 277/34 (2006.01), C07D 417/12 (2006.01)
Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street, P.O. Box 3190, 49131 Petah Tiqva (IL) (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road, P.O. Box 1090, North Wales, PA 19454-1090 (US) (BB only).
DOLITZKY, Ben-Zion [IL/IL]; (IL) (For US Only)
Inventors: DOLITZKY, Ben-Zion; (IL)
Agent: BRAINARD, Charles, R.; Kenyon & Kenyon, One Broadway, New York, NY 10004-1050 (US)
Priority Data:
60/342,437 20.12.2001 US
Title (EN) HYDROGENATION OF PRECURSORS TO THIAZOLIDINEDIONE ANTIHYPERGLYCEMICS
(FR) HYDROGENATION DE PRECURSEURS DE SUBSTANCES ANTI-HYPERGLYCEMIANTES DE THIAZOLIDINEDIONE
Abstract: front page image
(EN)Provided is a method of hydrogenating the exocyclic double bond of a thiazolidinedione precursor in a method of making a thiazolidinedione antihyperglycemic, for example pioglitazone, including work−up steps to afford pure thiazolidinedione antihyperglycemic.
(FR)L'invention concerne une méthode d'hydrogénation de la double liaison exocyclique d'un précurseur de thiazolidinédione dans une méthode de fabrication d'une substance anti-hyperglycémiante de thiazolidinédione, par exemple le pioglitazone, comprenant des étapes permettant d'obtenir des substances antihyperglycémiantes de thiazolidinédione pures.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)