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1. (WO2003046212) METHOD FOR IDENTIFYING TARGET EPITOPES OF THE T CELL MEDIATED IMMUNE RESPONSE AND FOR ASSAYING EPITOPE-SPECIFIC T CELLS

Pub. No.:    WO/2003/046212    International Application No.:    PCT/DE2002/004270
Publication Date: Fri Jun 06 01:59:59 CEST 2003 International Filing Date: Thu Nov 21 00:59:59 CET 2002
IPC: C07K 14/705
C12N 15/10
C12N 15/85
G01N 33/50
G01N 33/68
Applicants: DEML, Ludwig
Inventors: DEML, Ludwig
Title: METHOD FOR IDENTIFYING TARGET EPITOPES OF THE T CELL MEDIATED IMMUNE RESPONSE AND FOR ASSAYING EPITOPE-SPECIFIC T CELLS
Abstract:
The invention relates to a method for assaying epitope-specific T cells and target epitopes of reactive T cells. The present invention further relates to vectors, comprising a first promoter that can be specifically induced in antigen-presenting cells by the epitope-specific contact with a T cell, a nucleic acid functionally linked with said first promoter and encoding a marker gene, a second promoter that is constitutive in antigen-presenting cells, and a nucleic acid that is functionally linked with said second promoter. The present invention further relates to antigen-presenting cells that are transduced with the vectors according to the invention.