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1. WO2003037381 - VAGINALLY ADMINISTERD ANTI-DYSRHYTHMIC AGENTS FOR TREATING PELVIC PAIN AND INFERTILITY

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Publication Number WO/2003/037381
Publication Date 08.05.2003
International Application No. PCT/EP2002/012042
International Filing Date 28.10.2002
Chapter 2 Demand Filed 21.05.2003
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/137 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/245 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
24having an amino or nitro group
245Amino benzoic acid types, e.g. procaine, novocaine
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/137
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine ; or methadone
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61K 31/245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
24having an amino or nitro group
245Amino benzoic acid types, e.g. procaine, novocaine
A61K 31/554
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
554having at least one nitrogen and one sulfur as ring hetero atoms, e.g. chlothiapine, diltiazem
Applicants
  • COLUMBIA LABORATORIES (BERMUDA) LIMITED [--]/[--] (AllExceptUS)
  • LEVINE, Howard, L. [US]/[US] (UsOnly)
  • BOLOGNA, William, J. [US]/[FR] (UsOnly)
  • DE ZIEGLER, Dominique [CH]/[CH] (UsOnly)
Inventors
  • LEVINE, Howard, L.
  • BOLOGNA, William, J.
  • DE ZIEGLER, Dominique
Agents
  • KEEN, Celia, Mary
Priority Data
10/278,91224.10.2002US
60/330,68429.10.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) VAGINALLY ADMINISTERD ANTI-DYSRHYTHMIC AGENTS FOR TREATING PELVIC PAIN AND INFERTILITY
(FR) AGENTS ANTIDYSRYTHMIQUES ADMINISTRES PAR VOIE VAGINALE UTILISES POUR TRAITER LES DOULEURS PELVIENNES ET LA STERILITE
Abstract
(EN) The invention relates to a pharmaceutical composition for relieving pelvic pain or infertility associated with uterine dysrhythmia. The composition includes a locally-administered anti-dysrhythmic treating agent and a bioadhesive extended-release carrier. The composition may be delivered in an extended release formulation that includes a bioadhesive, water-swellable , water-insoluble, cross-linked polycarboxylic acid polymer, such as polycarbophil. The treating agent may be a local anesthetic, such as lidocaine. The invention also relates to a method of treating or preventing pelvic pain, or treating or improving infertility, by inserting a mixture of an anti-dysrhythmic treating agent and a bioadhesive carrier into the vagina of the patient to be treated.
(FR) L'invention concerne une composition pharmaceutique destinée à traiter les douleurs pelviennes ou la stérilité associées à une dysrythmie utérine. Cette composition comprend un agent de traitement antidysrythmique administré localement et un excipient bioadhésif à libération prolongée. Elle peut se présenter sous forme de formulation à libération prolongée comprenant un polymère d'acide polycarboxylique réticulé, bioadhésif, gonflant dans l'eau et insoluble dans l'eau, tel que le polycarbophile. L'agent de traitement peut être un anesthésiant local, tel que la lidocaïne. L'invention concerne en outre une méthode pour traiter ou prévenir les douleurs pelviennes, ou pour traiter ou soigner la stérilité, cette méthode consistant à introduire un mélange d'un agent de traitement antidysrythmique et d'un excipient bioadhésif dans le vagin de la patiente à traiter.
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