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1. (WO2003026577) P-AMIDOBENZYLETHERS IN DRUG DELIVERY AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2003/026577 International Application No.: PCT/US2002/030282
Publication Date: 03.04.2003 International Filing Date: 24.09.2002
Chapter 2 Demand Filed: 23.04.2003
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
SEATTLE GENETICS, INC. [US/US]; 21823 30th Drive, S.E. Bothell, WA 98021, US (AllExceptUS)
SENTER, Peter, D. [US/US]; US (UsOnly)
TOKI, Brian, E. [US/US]; US (UsOnly)
Inventors:
SENTER, Peter, D.; US
TOKI, Brian, E.; US
Agent:
ANTLER, Adriane, M. ; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
09/963,10324.09.2001US
10/252,94723.09.2002US
Title (EN) P-AMIDOBENZYLETHERS IN DRUG DELIVERY AGENTS
(FR) P-AMINOBENZYL ETHER DANS DES AGENTS D'ADMINISTRATION DE MEDICAMENTS
Abstract:
(EN) Compounds of the fonnulas L-[-An-Z-X-Ww-]-D and B-[-Z-X-Ww-]-D, wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
(FR) L'invention concerne des composés représentés par la formule L-[-An-Z-X-Ww-]-D et B-[-Z-X-Ww-]-D, dans laquelle D représente une fraction médicamenteuse ; L représente un ligand ; B représente un groupe de blocage ; A représente une unité acyle optionnelle ; Z représente un acide aminé ou un peptide ; X représente un groupe d'espacement aminobenzyl éther auto-immolateur ; W représente un second groupe d'espacement auto-immolateur optionnel ; n représente un entier 0 ou 1; et w représente un entier 0 ou 1. L'invention concerne également des compositions desdits composés comprenant un support, un diluant et/ou un excipient acceptables sur le plan pharmaceutique ainsi que des méthodes permettant d'administrer le médicament D au moyen desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2002339993