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1. (WO2003024430) MORPHINE POLYMER RELEASE SYSTEM
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/024430 International Application No.: PCT/DK2002/000619
Publication Date: 27.03.2003 International Filing Date: 23.09.2002
Chapter 2 Demand Filed: 15.04.2003
IPC:
A61K 9/00 (2006.01) ,A61K 9/20 (2006.01) ,A61K 9/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
Applicants:
FISCHER, Gina [DK/DK]; DK (UsOnly)
BAR-SHALOM, Daniel [IL/DK]; DK (UsOnly)
SLOT, Lillian [DK/DK]; DK (UsOnly)
JENSEN, Christine [DK/DK]; DK (UsOnly)
EGALET A/S [DK/DK]; Lejrvej 39-41 Kirke Værløse DK-3500 Værløse, DK (AllExceptUS)
Inventors:
FISCHER, Gina; DK
BAR-SHALOM, Daniel; DK
SLOT, Lillian; DK
JENSEN, Christine; DK
Agent:
ALBIHNS A/S; H.C. Andersens Boulevard 49 DK-1553 Copenhagen V, DK
Priority Data:
PA 2001 0137621.09.2001DK
Title (EN) MORPHINE POLYMER RELEASE SYSTEM
(FR) SYSTEME A LIBERATION DE POLYMERE DE MORPHINE
Abstract:
(EN) A pharmaceutical composition for controlled release of an active substance. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating. Zero order release is desirable. The matrix typically comprises PEO and the active substance is typically an opioid such as morphine or a glucuronide thereof. The coating comprises a first cellulose derivative which is substantially insoluble in the aqueous medium and at least one of a) a second cellulose derivative which is soluble or dispersible in water, b) a plasticizer, and, d) a filler.
(FR) La présente invention concerne une composition pharmaceutique destinée à la libération contrôlée d'une substance active. La libération de la substance active, qui intervient dans un milieu aqueux, se fait par érosion d'au moins une surface de la composition. Cette composition comprend i) une matrice enrobée ii) d'un enrobage. La matrice est constituée a) d'un polymère ou d'un mélange de polymères, b) d'une substance active, et éventuellement, c) d'un ou plusieurs excipients pharmaceutiquement admis. Une libération d'ordre zéro est souhaitable. La matrice comprend généralement un oxyde de polyéthylène, le principe actif étant généralement un opioïde tel que la morphine ou l'un de ses glucuronides. L'enrobage comprend un premier dérivé cellulosique sensiblement insoluble en milieu aqueux, et l'un au moins parmi a) un second dérivé cellulosique soluble ou dispersible dans l'eau, b) un plastifiant, et, d) une matière de remplissage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)