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1. WO2003020296 - INHIBITION OF ANGIOGENESIS AND DESTRUCTION OF ANGIOGENIC VESSELS WITH EXTRACTS OF NONI JUICE $i(MORINDA CITRIFOLIA)

Publication Number WO/2003/020296
Publication Date 13.03.2003
International Application No. PCT/US2002/027579
International Filing Date 30.08.2002
Chapter 2 Demand Filed 27.02.2003
IPC
C08B 37/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
CPC
A23L 2/02
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
2Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
02containing fruit or vegetable juices
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 36/746
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
74Rubiaceae (Madder family)
746Morinda
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE [US]/[US] (AllExceptUS)
  • WOLTERING, Eugene, A. [US]/[US] (UsOnly)
  • HORNICK, Conrad, A. [US]/[US] (UsOnly)
  • MYERS, Amy, E. [US]/[US] (UsOnly)
Inventors
  • WOLTERING, Eugene, A.
  • HORNICK, Conrad, A.
  • MYERS, Amy, E.
Agents
  • DAVIS, Bonnie, J.
Priority Data
60/316,52931.08.2001US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF ANGIOGENESIS AND DESTRUCTION OF ANGIOGENIC VESSELS WITH EXTRACTS OF NONI JUICE $i(MORINDA CITRIFOLIA)
(FR) INHIBITION DE L'ANGIOGENESE ET DESTRUCTION DE VAISSEAUX ANGIOGENIQUES A L'AIDE D'EXTRAITS DE JUS DE NONI (MORINDA CITRIFOLIA)
Abstract
(EN)
Noni juice and a protein-free, alcohol precipitate of Noni juice inhibited angiogenesis in $i(in vitro) human angiogenesis models. When growth medium contained Noni juice at least over the range from about 2.5% to about 33% (by volume), angiogenesis was blocked. Moreover, Noni juice and an ethanol precipitate were able to destroy a pre-existing angiogenic response as well as prevent the development of new vessels. Noni juice was effective in inhibiting the growth of angiogenic vessels from breast cancer explants. It will also be effective in treating cancers and non-cancerous diseases whose response includes an increase in angiogenesis, e.g., retinopathy of prematurity, neovascular glaucoma, diabetic retinopathy, and psoriasis. The primary antiangiogenic component is believed to be a carbohydrate with a molecular weight less than about 6000 Daltons. In an initial experiment, oral administration of Noni juice appeared to adversely affect the antioangiogenic component(s) in the juice.
(FR)
Selon la présente invention, le jus de noni et un précipité alcoolisé dépourvu de protéines constitué de jus de noni inhibent l'angiogenèse dans des modèles d'angiogenèse humaine in vitro. Lorsque le milieu de croissance contient du jus de noni au moins au-dessus d'une plage comprise entre environ 2,5 % et environ 33 % (en volume), l'angiogenèse est bloquée. De plus, du jus de noni et un précipité d'éthanol peuvent détruire une réponse angiogénique déjà existante et empêcher le développement de nouveaux vaisseaux. Le jus de noni est efficace pour inhiber la croissance de vaisseaux angiogéniques d'explants de cancer du sein. Il est également efficace pour le traitement de cancers et de maladies non cancéreuses dont la réponse comprend une augmentation au niveau de l'angiogenèse, par exemple, la rétinopathie des prématurés, le glaucome néovasculaire, la rétinopathie diabétique et le psoriasis. On pense que le constituant antiangiogénique primaire est un glucide présentant un poids moléculaire inférieur à environ 6 000 daltons. Dans une expérience initiale, l'administration orale de jus de noni a semblé affecter négativement le(s) constituant(s) antiangiogénique(s) présent(s) dans le jus.
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