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1. (WO2003020282) THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/020282 International Application No.: PCT/GB2002/003903
Publication Date: 13.03.2003 International Filing Date: 23.08.2002
Chapter 2 Demand Filed: 13.03.2003
IPC:
C07D 498/04 (2006.01) ,C07D 498/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
HODSON, Harold, Francis [GB/GB]; GB (UsOnly)
DUNK, Christopher, Robert [GB/GB]; GB (UsOnly)
PALMER, Richard, Michael, John [GB/GB]; GB (UsOnly)
MITCHELL, Dale, Robert [GB/GB]; GB (UsOnly)
BIRAULT, Véronique [FR/GB]; GB (UsOnly)
HUNT, Russell, George [GB/GB]; GB (UsOnly)
ALIZYME THERAPEUTICS LIMITED [GB/GB]; Granta Park Great Abington Cambridgeshire CB1 6GX, GB (AllExceptUS)
Inventors:
HODSON, Harold, Francis; GB
DUNK, Christopher, Robert; GB
PALMER, Richard, Michael, John; GB
MITCHELL, Dale, Robert; GB
BIRAULT, Véronique; GB
HUNT, Russell, George; GB
Agent:
CORNISH, Kristina, Victoria, Joy ; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ, GB
Priority Data:
0121019.430.08.2001GB
0206031.714.03.2002GB
Title (EN) THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY
(FR) ACTIVITE D'INHIBITION DE
Abstract:
(EN) The use of a compound comprising formula (I), or a salt, ester, amide or prodrug thereof in the treatment of obesity and related disorders. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I): A is an optionally substituted thienyl moiety, Y is O, S, or NR2, R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups and R2 is hydrogen or a group as defined for R1.
(FR) L'invention concerne l'utilisation d'un composé de formule (I), ou d'un sel, d'un ester, d'un amide ou d'un prodrogue dudit composé utile dans le traitement de l'obésité et de troubles associés. L'invention concerne également de nouveaux composés de formule (I), des procédés de préparation de ces composés et des compositions pharmaceutiques les contenant. Dans la formule (I), A représente une fraction thiényl éventuellement substituée, Y représente O, S, ou NR2, R1 est un alkyle réticulé ou non réticulé (éventuellement interrompu par un ou plusieurs atomes d'oxygène), alcényle, alcynyle, cycloalkyle, cycloalcényle, aryle, arylalkyle, arylalkyle réduit, arylalcényle, hétéroaryle, hétéroarylalkyle, hétéroarylalcényle, aryle réduit, hétéroaryle réduit, hétéroarylalkyle réduit ou un dérivé substitué d'un quelconque des groupes précédents, et R2 représente hydrogène ou un groupe comme défini pour R1.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)