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1. (WO2003020172) AN IMPLANTABLE AND SEALABLE SYSTEM FOR UNIDIRECTIONAL DELIVERY OF THERAPEUTIC AGENTS TO TARGETED TISSUES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2003/020172 International Application No.: PCT/US2002/027434
Publication Date: 13.03.2003 International Filing Date: 28.08.2002
IPC:
A61F 2/00 (2006.01) ,A61F 2/02 (2006.01) ,A61F 9/00 (2006.01) ,A61K 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9
Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
Applicants:
DE CARVALHO, Ricardo, A., P. [BR/US]; US
MURPHREE, A., Linn [US/US]; US
SCHMITT, Ed [US/US]; US
Inventors:
DE CARVALHO, Ricardo, A., P.; US
MURPHREE, A., Linn; US
SCHMITT, Ed; US
Priority Data:
60/315,95229.08.2001US
Title (EN) AN IMPLANTABLE AND SEALABLE SYSTEM FOR UNIDIRECTIONAL DELIVERY OF THERAPEUTIC AGENTS TO TARGETED TISSUES
(FR) SYSTEME SCELLABLE ET IMPLANTABLE DESTINE A ADMINISTRER DES AGENTS THERAPEUTIQUES A DES TISSUS DE FAÇON UNIDIRECTIONNELLE
Abstract:
(EN) A surgically implantable and sealable delivery device that upon contact of its contents via an interface window or port therein with an organ or tissue exposes a therapeutic agent to the organ or tissue surface, allowing a controlled, selective and unidirectional diffusion of the agent into the tissue or organ. The device protects adjacent organs or tissue structures form unnecessary high levels of the delivered agent. Novel methods to deliver chemotherapeutics or bioactive agents to mammalian organs or tissues through a surgically implanted device by the way of a selective and protected diffusion mechanism are disclosed as well as method to achieve the sealing properties of the device.
(FR) L'invention concerne un dispositif d'administration scellable et implantable du point de vue chirurgical qui, au contact de son contenu via une fenêtre ou un orifice d'interface avec un organe ou un tissu exposant un agent thérapeutique à une surface d'organe ou de tissu, permet une diffusion contrôlée sélective et unidirectionnelle de l'agent dans le tissu ou l'organe. Ce dispositif protège des organes ou des structures de tissu adjacents des niveaux élevés non nécessaires de l'agent administré. L'invention concerne également de nouveaux procédés d'administration d'agents chimiothérapeutiques ou bioactifs à des organes ou des tissus mammaliens par le biais du dispositif implanté chirurgicalement au moyen d'un mécanisme de diffusion protégé et sélectif. L'invention concerne enfin un procédé destiné à réaliser les propriétés de scellement du dispositif.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
ZA2003/04159BRPI205990EP1420716JP2005501602RU02311892ES2393101
CN1578647CA2456025AU2002324811