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1. (WO2003008409) QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/008409    International Application No.:    PCT/GB2002/003177
Publication Date: 30.01.2003 International Filing Date: 10.07.2002
Chapter 2 Demand Filed:    15.01.2003    
IPC:
C07D 405/12 (2006.01), C07D 405/14 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; Sodertalje, S-151 85 (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1Y 6LN (GB) (MG only).
HENNEQUIN, Laurent, Francois, Andre [FR/GB]; (GB) (For US Only)
Inventors: HENNEQUIN, Laurent, Francois, Andre; (GB)
Agent: TAIT, Brian, Steele; Astrazeneca, Global Intellectual Property, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG (GB)
Priority Data:
01401895.6 16.07.2001 EP
01403123.1 05.12.2001 EP
Title (EN) QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS
(FR) DERIVES QUINOLINE ET UTILISATION EN TANT QU'INHIBITEURS DE TYROSINE KINASE
Abstract: front page image
(EN)The invention concerns quinoline derivatives of Formula (I) wherein each of Z, m, R1, n and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
(FR)L'invention concerne des dérivés quinoline de formule (1) dans laquelle Z, m, R1, n et R3 ont les significations données dans le descriptif. L'invention concerne également des procédés de fabrication de ces dérivés, des compositions pharmaceutiques contenant lesdits dérivés, ainsi que leur utilisation dans la fabrication d'un médicament servant d'agent anti-invasif dans le confinement et/ou le traitement de maladies de tumeurs solides.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)