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Machine translation
1. (WO2003008406) IMPROVED PROCESS FOR PREPARING BENZIMIDAZOLE-TYPE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/008406    International Application No.:    PCT/EP2002/007693
Publication Date: 30.01.2003 International Filing Date: 09.07.2002
Chapter 2 Demand Filed:    21.12.2002    
IPC:
C07D 401/12 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE) (For All Designated States Except US).
BROECKX, Rudy, Laurent, Maria [BE/BE]; (BE) (For US Only).
DE SMAELE, Dirk [BE/BE]; (BE) (For US Only).
LEURS, Stefan, Marcel, Herman [BE/BE]; (BE) (For US Only)
Inventors: BROECKX, Rudy, Laurent, Maria; (BE).
DE SMAELE, Dirk; (BE).
LEURS, Stefan, Marcel, Herman; (BE)
Common
Representative:
JANSSEN PHARMACEUTICA N.V. Filip Verberckmoes J & J Patent Law Department; Turnhoutseweg 30, B-2340 Beerse (BE)
Priority Data:
01202696.9 16.07.2001 EP
Title (EN) IMPROVED PROCESS FOR PREPARING BENZIMIDAZOLE-TYPE COMPOUNDS
(FR) PROCEDE AMELIORE DE PREPARATION DE COMPOSES DE TYPE BENZIMIDAZOLE
Abstract: front page image
(EN)The present invention relates to an improved process for the preparation of proton pump inhibitors of the benzimidazole-type such as rabeprazole, omeprazole, pantoprazole, lansoprazole and esome prazole, of general formula (1) by oxidation of the corresponding sulfide followed by extraction of the sulfone by-product with an acqueous alkaline solution at controlled pH.
(FR)Cette invention concerne un procédé amélioré de préparation d'inhibiteurs de la pompe à protons du type benzimidazole, tels que le rabéprazole, l'oméprazole, le pantoprazole, le lansoprazole et l'ésoméprazole, représentés par la formule générale (I), lequel procédé consiste à oxyder le sulfure correspondant puis à extraire le produit inutile de sulfone au moyen d'une solution alcaline aqueuse à un pH donné.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)