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1. (WO2003008387) COMPOUNDS USEFUL FOR TREATMENT OR PREVENTION OF DISEASE MEDIATED BY ALPHA-2B-ADRENOCEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/008387 International Application No.: PCT/FI2002/000643
Publication Date: 30.01.2003 International Filing Date: 22.07.2002
Chapter 2 Demand Filed: 15.01.2003
IPC:
C07D 239/42 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants: JOUTSAMO, Topi[FI/FI]; FI (UsOnly)
TAUBER, Andrei, Yurievitch[RU/FI]; FI (UsOnly)
SALO, Harri[FI/FI]; FI (UsOnly)
HOFFRÉN, Anna-Marja[FI/FI]; FI (UsOnly)
WURSTER, Siegfried[DE/FI]; FI (UsOnly)
OY JUVANTIA PHARMA LTD[FI/FI]; Lemminkäisenkatu 5 FIN-20520 Turku, FI (AllExceptUS)
Inventors: JOUTSAMO, Topi; FI
TAUBER, Andrei, Yurievitch; FI
SALO, Harri; FI
HOFFRÉN, Anna-Marja; FI
WURSTER, Siegfried; FI
Agent: TURUN PATENTTITOIMISTO OY; P.O. Box 99 FIN-20521 Turku, FI
Priority Data:
2001156020.07.2001FI
60/306,44920.07.2001US
Title (EN) COMPOUNDS USEFUL FOR TREATMENT OR PREVENTION OF DISEASE MEDIATED BY ALPHA-2B-ADRENOCEPTOR
(FR) COMPOSES UTILES POUR LE TRAITEMENT OU LA PREVENTION D'UNE MALADIE INDUITE PAR L'ALPHA-2B-ADRENORECEPTEUR
Abstract:
(EN) The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4 and R5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, -OH or =O; Z is H, acetyl, -CH2-Ph-O-CF3 or CH2-Ph-CF3, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. This invention further relates to the use of said compounds for the manufacture of a pharmaceutical preparation useful for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.
(FR) L'invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable desdits composés. Dans cette formule, R1, R2, R3, R4 et R5, indépendamment les uns des autres, sont H, un groupe alkyle ou alcoxy linéaire ou ramifié avec 1 à 4 atomes de carbone, ou un halogène, X est H, une chaîne alkyle linéaire ou ramifié avec 1 à 4 atomes de carbone, phényle OH ou =O, Z est H, acétyle, -CH2-Ph-O-CF3 ou CH2-Ph-CF3, et Y est une structure cyclique éventuellement associée à la formule (I) avec une chaîne alkyle comprenant un ou deux atomes de carbone. L'invention concerne en outre l'utilisation de ces composés pour la fabrication d'une préparation pharmaceutique utile dans le traitement ou la prévention d'une maladie induite par l'alpha-2B-adrénorécepteur chez un mammifère.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)