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1. WO2003008374 - INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES

Publication Number WO/2003/008374
Publication Date 30.01.2003
International Application No. PCT/US2002/023025
International Filing Date 18.07.2002
Chapter 2 Demand Filed 19.02.2003
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07C 311/51 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
50Compounds containing any of the groups X being a hetero atom, Y being any atom
51Y being a hydrogen or a carbon atom
C07K 5/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
C07K 5/065 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
065the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
CPC
A61K 38/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants
  • IDUN PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • TERNANSKY, Robert, J. [US]/[US] (UsOnly)
  • GLADSTONE, Patricia, L. [CA]/[US] (UsOnly)
  • TOMASELLI, Kevin, J. [US]/[US] (UsOnly)
  • CHAO, Bin [CN]/[US] (UsOnly)
  • LINTON, Steven, D. [US]/[US] (UsOnly)
Inventors
  • TERNANSKY, Robert, J.
  • GLADSTONE, Patricia, L.
  • TOMASELLI, Kevin, J.
  • CHAO, Bin
  • LINTON, Steven, D.
Agents
  • HERMANNS, Karl, R.
Priority Data
09/908,96918.07.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES
(FR) INHIBITEURS DE LA FAMILLE DES CYSTEINE PROTEASES ICE/CED-3
Abstract
(EN) This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure (I), wherein A, B, R, R1, R1 p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
(FR) L'invention concerne de nouveaux composés inhibiteurs de la famille des oxamyl dipeptide ICE/ced-3, qui possèdent la structure (I), A, B, R, R1, R1' <i>p</i> et <i>q</i> étant tels que définis dans la demande. L'invention concerne aussi des compositions pharmaceutiques contenant un ou plusieurs de ces composés, ainsi que l'utilisation de ces compositions pour traiter des patients atteints de maladies inflammatoires, auto-immunes et neurodégénératives, prévenir des lésions ischémiques et conserver des organes destinés à une greffe.
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