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Pub. No.:    WO/2003/008003    International Application No.:    PCT/US2002/023222
Publication Date: 30.01.2003 International Filing Date: 19.07.2002
Chapter 2 Demand Filed:    18.02.2003    
A61B 17/08 (2006.01), A61F 13/02 (2006.01), A61L 15/58 (2006.01), A61L 24/00 (2006.01), A61L 24/06 (2006.01)
Applicants: LOMA LINDA UNIVERSITY MEDICAL CENTER [US/US]; 24888 Prospect St., Loma Linda, CA 92350 (US) (For All Designated States Except US).
ZHU, Yong-Hua [US/US]; (US) (For US Only).
KIRSCH, Wolff, M. [US/US]; (US) (For US Only).
DICKSON, Cindy [US/US]; (US) (For US Only).
GU, Min, Di [CN/CN]; (CN) (For US Only).
YANG, Chang, Zheng [CN/CN]; (CN) (For US Only).
SHEN, Qun-Dong [CN/CN]; (CN) (For US Only)
Inventors: ZHU, Yong-Hua; (US).
KIRSCH, Wolff, M.; (US).
DICKSON, Cindy; (US).
GU, Min, Di; (CN).
YANG, Chang, Zheng; (CN).
SHEN, Qun-Dong; (CN)
Agent: ALTMAN, Daniel, E.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, Fourteenth Floor, Irvine, CA 92614 (US)
Priority Data:
60/306,572 19.07.2001 US
60/308,993 31.07.2001 US
60/337,662 07.11.2001 US
60/341,598 17.12.2001 US
10/041,688 07.01.2002 US
Abstract: front page image
(EN)The present invention provides medicament-containing cyanoacrylate adhesive formulations for sealing wounds. The adhesive comprises a cyanoacrylate, a substance, and a defect forming agent, wherein the defect forming agent is capable of being removed from a cured cyanoacrylate matrix by solvation in an aqueous solution whereby a plurality of defects in the matrix are formed permitting release of the substance from the matrix at a controlled rate.
(FR)La présente invention concerne des formulations d'adhésif à base de cyanoacrylate renfermant un médicament cicatrisant. L'adhésif renferme un cyanoacrylate, une substance et un agent porogène. Cet agent porogène peut être retiré d'une matrice de cyanoacrylate durcie par solvatation d'une solution aqueuse dissolvante. La pluralité de pores formés dans la matrice assure une libération contrôlée de la substance hors de la matrice.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)