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1. (WO2003007874) ANTI-TUMOR ACTIVITY FROM REPTILE SERUM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/007874    International Application No.:    PCT/IL2002/000590
Publication Date: 30.01.2003 International Filing Date: 18.07.2002
Chapter 2 Demand Filed:    24.01.2003    
IPC:
A61K 38/17 (2006.01), A61K 47/48 (2006.01), C07K 16/30 (2006.01)
Applicants: NATURAL CURE LTD. [IL/IL]; Ruth Street 51, 34404 Haifa (IL) (For All Designated States Except US).
BINAH, Ofer [IL/IL]; (IL) (For US Only).
CIECHANOVER, Aaron [IL/IL]; (IL) (For US Only).
MAOR, Gila [IL/IL]; (IL) (For US Only)
Inventors: BINAH, Ofer; (IL).
CIECHANOVER, Aaron; (IL).
MAOR, Gila; (IL)
Agent: WEBB, Cynthia; Webb & Associates, P.O. Box 2189, 76121 Rehovot (IL)
Priority Data:
144447 19.07.2001 IL
Title (EN) ANTI-TUMOR ACTIVITY FROM REPTILE SERUM
(FR) ACTIVITE ANTITUMORALE UTILISANT LE SERUM DE REPTILES
Abstract: front page image
(EN)The invention discloses anti-tumor activity in the sera of certain reptiles, more particularly in the serum of alligators or crocodiles. The active principle resides in one or more serum proteins or polypeptides that inhibit the growth of mammalian tumor cells in culture while being practically devoid of such inhibitory activity towards normal cells in culture. The active fractions obtained from the sera show no overt toxicity in healthy mammals, and this novel anti-tumor agent may therefore be used for the prevention, investigation, treatment or diagnosis of neoplasms.
(FR)L'invention concerne l'activité antitumorale manifestée dans le sérum de certains reptiles et notamment dans le sérum des alligators ou crocodiles. Le principe actif réside dans une ou plusieurs protéines ou un ou plusieurs polypeptides du sérum qui inhibent la croissance des cellules tumorales chez les mammaliens dans une culture tout en restant pratiquement exempts de cette activité d'inhibition par rapport aux cellules normales dans la culture. Les fractions actives obtenues à partir de ces sérums n'ont aucune toxicité manifeste chez les mammifères sains, et ce nouvel agent antitumoral peut ainsi être utilisé dans la prévention, la recherche, le traitement ou le diagnostic des néoplasmes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)