WO2003006643 A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO

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Publication Number WO/2003/006643

Publication Date 23.01.2003

International Application No. PCT/DK2002/000473

International Filing Date 08.07.2002

Chapter 2 Demand Filed 24.01.2003

IPC

CPC

Applicants

NOVO NORDISK A/S [DK]/[DK]

Inventors

SØNDERGAARD, Helle, Bach
ECHWALD, Søren, Morgenthaler
PEDERSEN, Oluf, Borbye

Priority Data

01610075.2

11.07.2001

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO

(FR) VARIANT P387L DE LA PROTEINE TYROSINE PHOSPHATASE-1B ASSOCIE AU DIABETE DE TYPE II ET DIMINUTION DE LA PHOSPHORYLATION SUR SERINE DE LA PTP-1B IN VITRO

Abstract

(EN) The present invention provides an isolated polynucleotide molecule comprising a nucleotide sequence encoding PTP-1B, said nucleotide sequence containing a mutation associated with type 2 diabetes of at least one nucleotide, or comprising a fragment of the nucleotide sequence including said mutation.

(FR) La présente invention concerne une molécule polynucléotidique isolée comprenant une séquence nucléotidique codant pour la PTP-1B, cette séquence nucléotidique renfermant une mutation associée au diabète de type II d'au moins un nucléotide, ou comprenant un fragment de la séquence nucléotidique contenant cette mutation.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14	Hydrolases (3.)
16	acting on ester bonds (3.1)

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14	Hydrolases (3.)
16	acting on ester bonds (3.1)

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

A	HUMAN NECESSITIES
01	AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K	ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217	Genetically modified animals
05	Animals comprising random inserted nucleic acids (transgenic)

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1. WO2003006643 - A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO