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1. WO2003006643 - A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO

Publication Number WO/2003/006643
Publication Date 23.01.2003
International Application No. PCT/DK2002/000473
International Filing Date 08.07.2002
Chapter 2 Demand Filed 24.01.2003
IPC
C12N 9/16 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
C12N 9/16
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
16acting on ester bonds (3.1)
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • NOVO NORDISK A/S [DK]/[DK]
Inventors
  • SØNDERGAARD, Helle, Bach
  • ECHWALD, Søren, Morgenthaler
  • PEDERSEN, Oluf, Borbye
Priority Data
01610075.211.07.2001EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO
(FR) VARIANT P387L DE LA PROTEINE TYROSINE PHOSPHATASE-1B ASSOCIE AU DIABETE DE TYPE II ET DIMINUTION DE LA PHOSPHORYLATION SUR SERINE DE LA PTP-1B IN VITRO
Abstract
(EN) The present invention provides an isolated polynucleotide molecule comprising a nucleotide sequence encoding PTP-1B, said nucleotide sequence containing a mutation associated with type 2 diabetes of at least one nucleotide, or comprising a fragment of the nucleotide sequence including said mutation.
(FR) La présente invention concerne une molécule polynucléotidique isolée comprenant une séquence nucléotidique codant pour la PTP-1B, cette séquence nucléotidique renfermant une mutation associée au diabète de type II d'au moins un nucléotide, ou comprenant un fragment de la séquence nucléotidique contenant cette mutation.
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