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Pub. No.:    WO/2003/006627    International Application No.:    PCT/US2002/022593
Publication Date: 23.01.2003 International Filing Date: 15.07.2002
Chapter 2 Demand Filed:    18.12.2002    
G01N 33/50 (2006.01), G01N 33/574 (2006.01)
Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US/US]; Nine Cambridge Center, Cambridge, MA 02142 (US) (For All Designated States Except US).
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 44 Binney Street, Boston, MA 02115 (US) (For All Designated States Except US).
GOLUB, Todd, R. [US/US]; (US) (For US Only).
SASAKI, Koichi [US/JP]; (JP) (For US Only).
MARTINEZ, Robert, V. [TT/US]; (US) (For US Only).
LANDER, Eric, S. [US/US]; (US) (For US Only)
Inventors: GOLUB, Todd, R.; (US).
SASAKI, Koichi; (JP).
MARTINEZ, Robert, V.; (US).
LANDER, Eric, S.; (US)
Agent: TREANNIE, Lisa, M.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Road, P.O. Box 9133, Concord, MA 01742-9133 (US)
Priority Data:
60/305,554 13.07.2001 US
Abstract: front page image
(EN)A previously unrecognized level of transcriptional control by the leukemogenic transcription factors TEL, and AML1/ETO, of the interferon gamma signaling pathway has been discovered. Gene expression analysis has identified downstream targets of these leukemogenic transcription factors. The associated expression and regulation of these genes in leukemia, and methods ofuse thereof, are described herein.
(FR)L'invention concerne un niveau, non préalablement reconnu, de régulation transcriptionnelle exercé par les facteurs de transcription leucémogènes TEL, et AML1/ETO, de la voie de signalisation de l'interféron gamma. L'analyse d'expression génique a permis d'identifier des cibles avals de ces facteurs de transcription leucémogènes. L'invention concerne aussi l'expression et la régulation de ces gènes dans la leucémie ainsi que des méthodes d'utilisation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)