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1. (WO2003006506) PROTEASE INHIBITOR CONJUGATES AND ANTIBODIES USEFUL IN IMMUNOASSAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/006506    International Application No.:    PCT/EP2002/007843
Publication Date: 23.01.2003 International Filing Date: 15.07.2002
Chapter 2 Demand Filed:    14.11.2002    
IPC:
C07K 16/38 (2006.01)
Applicants: ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Strasse 116, 68305 Mannheim (DE) (DE only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only)
Inventors: DERAS, INA; (US).
HUI, Raymond; (US).
SIGLER, Gerald, F.; (US).
HUBER, Erasmus, J.; (DE).
VON DER ELTZ, Herbert, W.; (DE).
GHOSHAL, Mitali; (US).
ROOT, Richard, Terry; (US).
METZ, Sigrun; (DE)
Priority Data:
60/305,192 13.07.2001 US
  10.07.2002 US
Title (EN) PROTEASE INHIBITOR CONJUGATES AND ANTIBODIES USEFUL IN IMMUNOASSAY
(FR) CONJUGUES D'INHIBITEURS DE PROTEASE ET ANTICORPS UTILES DANS UN DOSAGE IMMUNOLOGIQUE
Abstract: front page image
(EN)Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir and lopinavir.
(FR)L'invention concerne des haptènes activés utiles pour produire des immunogènes contre les inhibiteurs de protéase du VIH, des immunogènes utiles pour produire des anticorps dirigés contre les inhibiteurs de protéase du VIH, ainsi que des anticorps et des conjugués marqués utiles dans des dosages immunologiques d'inhibiteurs de protéase du VIH. Ces nouveaux haptènes comportent une fonctionnalité activée au groupe hydroxyle central non terminal commun à tous les inhibiteurs de protéase du VIH, p. ex. saquinavir, nelfinavir, indinavir, amprenavir, ritonavir et lopinavir.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)