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1. (WO2003006423) N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/006423    International Application No.:    PCT/US2002/022255
Publication Date: 23.01.2003 International Filing Date: 11.07.2002
Chapter 2 Demand Filed:    07.02.2003    
IPC:
C07C 233/40 (2006.01), C07C 235/20 (2006.01), C07C 235/34 (2006.01), C07C 271/22 (2006.01), C07C 311/06 (2006.01), C07C 323/62 (2006.01), C07D 207/26 (2006.01), C07D 207/327 (2006.01), C07D 209/08 (2006.01), C07D 209/12 (2006.01), C07D 209/18 (2006.01), C07D 209/30 (2006.01), C07D 209/48 (2006.01), C07D 211/76 (2006.01), C07D 213/38 (2006.01), C07D 213/56 (2006.01), C07D 213/64 (2006.01), C07D 213/74 (2006.01), C07D 231/12 (2006.01), C07D 233/54 (2006.01), C07D 235/16 (2006.01), C07D 235/26 (2006.01), C07D 237/14 (2006.01), C07D 239/20 (2006.01), C07D 241/08 (2006.01), C07D 241/12 (2006.01), C07D 249/04 (2006.01), C07D 249/08 (2006.01), C07D 249/12 (2006.01), C07D 249/18 (2006.01), C07D 257/04 (2006.01), C07D 261/10 (2006.01), C07D 263/56 (2006.01), C07D 263/57 (2006.01), C07D 263/58 (2006.01), C07D 265/14 (2006.01), C07D 271/06 (2006.01), C07D 275/04 (2006.01), C07D 277/34 (2006.01), C07D 277/46 (2006.01), C07D 277/70 (2006.01), C07D 295/088 (2006.01), C07D 295/155 (2006.01), C07D 307/52 (2006.01), C07D 307/54 (2006.01), C07D 307/79 (2006.01), C07D 307/81 (2006.01), C07D 307/91 (2006.01), C07D 311/58 (2006.01), C07D 317/28 (2006.01), C07D 317/60 (2006.01), C07D 319/18 (2006.01), C07D 321/02 (2006.01), C07D 333/22 (2006.01), C07D 333/24 (2006.01), C07D 401/04 (2006.01), C07D 403/04 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 413/04 (2006.01), C07D 417/04 (2006.01), C07D 473/02 (2006.01), C07D 487/04 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard, South San Francisco, Ca 94080 (US) (For All Designated States Except US).
PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta, Kalamazoo, MI 49007 (US) (For All Designated States Except US).
GAILUNAS, Andrea [US/US]; (US) (For US Only).
TUCKER, John, A. [US/US]; (US) (For US Only).
TENBRINK, Ruth [US/US]; (US) (For US Only).
MICKELSON, John [US/US]; (US) (For US Only)
Inventors: GAILUNAS, Andrea; (US).
TUCKER, John, A.; (US).
TENBRINK, Ruth; (US).
MICKELSON, John; (US)
Agent: DOCTER, Stephen, H.; McDonnell Boehnen Hulbert & Berghoff, 300 South Wacker Drive, Suite 3200, Chicago, IL 60606 (US)
Priority Data:
60/304,525 11.07.2001 US
60/308,756 30.07.2001 US
60/341,341 17.12.2001 US
60/341,416 17.12.2001 US
60/344,872 21.12.2001 US
60/380,574 21.12.2001 US
Title (EN) N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS
(FR) COMPOSES DE N-(3-AMINO-2-HYDROXY-PROPYL) ALKYLAMIDE SUBSTITUES
Abstract: front page image
(EN)Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
(FR)L'invention concerne des composés de formule (I), utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Les composés selon l'invention comprennent des inhibiteurs de l'enzyme bêta-sécrétase, utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies se caractérisant par le dépôt du peptide A bêta, chez un mammifère. Les composés selon l'invention peuvent être utilisés dans des compositions pharmaceutiques et des méthodes thérapeutiques visant à réduire la formation du peptide A bêta.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)