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Machine translation
1. (WO2003004692) SCREENING PROCESSES FOR AGENTS MODULATING CHOLESTEROL LEVELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004692    International Application No.:    PCT/CA2002/001001
Publication Date: 16.01.2003 International Filing Date: 03.07.2002
Chapter 2 Demand Filed:    15.11.2002    
IPC:
C12Q 1/42 (2006.01), C12Q 1/48 (2006.01)
Applicants: XENON GENETICS, INC. [CA/CA]; 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA) (For All Designated States Except US).
UNIVERSITY OF BRITISH COLUMBIA [CA/CA]; 2194 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3 (CA) (For All Designated States Except US).
SEE, Raymond [CA/CA]; (CA) (For US Only).
HAYDEN, Michael, R. [CA/CA]; (CA) (For US Only)
Inventors: SEE, Raymond; (CA).
HAYDEN, Michael, R.; (CA)
Agent: MBM & CO.; P.O. Box 809, Station B, Ottawa, Ontario K1P 5P9 (CA)
Priority Data:
60/302,854 03.07.2001 US
PCT/CA02/01085 02.07.2002 CA
Title (EN) SCREENING PROCESSES FOR AGENTS MODULATING CHOLESTEROL LEVELS
(FR) PROCEDES DE CRIBLAGE D'AGENTS MODULANT LES TAUX DE CHOLESTEROL
Abstract: front page image
(EN)Methods for identifying agents that modulate the extent of phosphorylation of the protein product of the ABC1 gene through increase in the activity of ABCA1 phosphorylating enzymes, especially protein kinases, including protein kinase A (PKA) and protein kinase C (PKC) or by decreasing the activity of ABCA1 dephosphorylases, or phosphatases, especially Protein Phosphatase 1 (PP1) are disclosed. These processes include both in vitro and cell based assays. Also disclosed are processes for preventing diseases linked to the activity of ABCA1 activity by administering to a patient at risk of such diseases an amount of an agent that inhibits ABCA1 phosphatases or increases the activity of ABCA1 kinases.
(FR)L'invention concerne des procédés permettant d'identifier des agents qui modulent la portée de la phosphorylation du produit protéique du gène ABC1 par le biais de l'augmentation de l'activité des enzymes de phosphorylation d'ABCA1, en particulier des protéines kinase, y compris la protéine kinase A (PKA) et la protéine kinase C (PKC), ou de la diminution de l'activité de ABCA1 déphosphorylases, ou de phosphatases, notamment la protéine phosphatase 1 (PP1). Ces procédés comportent des dosage aussi bien in vitro que cellulaires. L'invention concerne également des procédés permettant de prévenir des maladies liées à l'activité de ABCA1 par administration au patient à risque une dose d'un agent qui inhibe les ABCA1 phosphatases ou les augmentations de l'activité des ABCA1 kinases.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)