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Pub. No.:    WO/2003/004623    International Application No.:    PCT/US2002/009922
Publication Date: 16.01.2003 International Filing Date: 26.03.2002
Chapter 2 Demand Filed:    25.10.2002    
A61K 38/00 (2006.01), C07K 14/47 (2006.01)
Applicants: HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue, Rockville, MD 20850 (US) (For All Designated States Except US).
ROSEN, Craig, A. [US/US]; (US) (For US Only).
RUBEN, Steven, M. [US/US]; (US) (For US Only)
Inventors: ROSEN, Craig, A.; (US).
RUBEN, Steven, M.; (US)
Agent: HOOVER, Kenley, K.; Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD 20850 (US)
Priority Data:
60/278,650 27.03.2001 US
09/950,082 12.09.2001 US
09/950,083 12.09.2001 US
Abstract: front page image
(EN)The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
(FR)La présente invention concerne des polypeptides humains sécrétés et des molécules d'acide nucléique isolées codantes pour ces polypeptides, utiles pour le diagnostic et le traitement de maladies cardiovasculaires, de troubles et/ou d'états liés à ces derniers. L'invention concerne également des anticorps qui lient ces polypeptides ainsi que des vecteurs, des cellules hôtes et des procédés recombinants et synthétiques pour la production de ces polynucléotides, polypeptides et/ou anticorps. L'invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et antagonistes de polynucléotides et polypeptides de l'invention ainsi que des procédés et compositions permettant d'inhiber ou d'améliorer la production et le fonctionnement des polypeptides de la présente invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)