Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2003004602) NUCLEASE RESISTANT CHIMERIC OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2003/004602 International Application No.: PCT/US2002/020934
Publication Date: 16.01.2003 International Filing Date: 01.07.2002
Chapter 2 Demand Filed: 16.01.2003
IPC:
C07H 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants:
ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue Carlsbad, CA 92009, US (AllExceptUS)
MANOHARAN, Muthiah [US/US]; US (UsOnly)
MAIER, Martin, A. [DE/US]; US (UsOnly)
PRAKASH, Thazha, P. [IN/US]; US (UsOnly)
RAJEEV, Kallanthottathil, Gopalan [IN/US]; US (UsOnly)
Inventors:
MANOHARAN, Muthiah; US
MAIER, Martin, A.; US
PRAKASH, Thazha, P.; US
RAJEEV, Kallanthottathil, Gopalan; US
Agent:
INGLESE, Jane, E.; Woodcock Washburn LLP One Liberty Place - 46th Floor Philadelphia, PA 19103, US
Priority Data:
09/996,29228.11.2001US
10/013,29510.12.2001US
60/302,68203.07.2001US
Title (EN) NUCLEASE RESISTANT CHIMERIC OLIGONUCLEOTIDES
(FR) OLIGONUCLEOTIDES CHIMERES RESISTANTS A LA NUCLEASE
Abstract:
(EN) The present invention relates to novel nuclease-resistant oligomeric compounds and to novel methods for increasing resistance of oligomeric compounds. In preferred embodiments of the invention, the oligomeric compounds comprise at least one modified nucleoside containing a modified sugar moiety at either the 3' or 5' terminus of the oligomeric compound, and further comprise at least one internucleoside linking group that is other than phosphodiester. Other preferred embodiments of the invention include methods of enhancing the nuclease resistance of oligomeric compounds comprising incorporating at least one modified nucleoside containing a modified sugar moiety at either the 3' or 5' terminus of an oligomeric compound.
(FR) L'invention concerne de nouveaux composés oligomères résistants à la nucléase, et de nouveaux procédés permettant d'accroître la résistance des composés oligomères. Dans les modes de réalisation préférés, ces composés oligomères comprennent au moins un nucléoside modifié contenant une fraction sucre modifiée au niveau de l'extrémité 3' ou 5' du composé oligomère, ainsi qu'au moins un groupe de liaison internucléosides autre que le phosphodiester. D'autres formes de réalisation préférées comprennent des procédés permettant d'augmenter la résistance à la nucléase des composés oligomères, consistant à incorporer au moins un nucléoside modifié contenant une fraction sucre modifié dans l'extrémité 3' ou 5' d'un composé oligomère.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1499627JP2005504020CA2452458AU2002316502