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1. (WO2003004503) MORPHOLINE-BRIDGED PYRAZOLOPYRIDINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004503    International Application No.:    PCT/EP2002/006991
Publication Date: 16.01.2003 International Filing Date: 25.06.2002
Chapter 2 Demand Filed:    14.01.2003    
IPC:
C07D 471/04 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
FEURER, Achim [DE/DE]; (DE) (For US Only).
FLUBACHER, Dietmar [DE/DE]; (DE) (For US Only).
WEIGAND, Stefan [DE/DE]; (DE) (For US Only).
STASCH, Johannes-Peter [DE/DE]; (DE) (For US Only).
STAHL, ELke [DE/DE]; (DE) (For US Only).
SCHENKE, Thomas [DE/DE]; (DE) (For US Only).
ALONSO-ALIJA, Cristina [ES/DE]; (DE) (For US Only).
WUNDER, Frank [DE/DE]; (DE) (For US Only).
LANG, Dieter [DE/DE]; (DE) (For US Only).
DEMBOWSKY, Klaus [DE/US]; (US) (For US Only).
STRAUB, Alexander [DE/DE]; (DE) (For US Only).
PERZBORN, Elisabeth [DE/DE]; (DE) (For US Only)
Inventors: FEURER, Achim; (DE).
FLUBACHER, Dietmar; (DE).
WEIGAND, Stefan; (DE).
STASCH, Johannes-Peter; (DE).
STAHL, ELke; (DE).
SCHENKE, Thomas; (DE).
ALONSO-ALIJA, Cristina; (DE).
WUNDER, Frank; (DE).
LANG, Dieter; (DE).
DEMBOWSKY, Klaus; (US).
STRAUB, Alexander; (DE).
PERZBORN, Elisabeth; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
101 32 416.2 04.07.2001 DE
Title (DE) MORPHOLIN-ÜBERBRÜCKTE PYRAZOLOPYRIDINDERIVATE
(EN) MORPHOLINE-BRIDGED PYRAZOLOPYRIDINE DERIVATIVES
(FR) DERIVES DE PYRAZOLOPYRIDINE PONTES AVEC LA MORPHOLINE
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft neue Pyrazolopyridinderivate der Formel (I), worin R1 für (a) oder (b) und n für 1 oder 2 steht; R2 für H oder NH2 steht; sowie Salze, Isomere und Hydrate davon, als Stimulatoren der löslichen Guanylatcyclase und zur Verwendung als Mittel zur Behandlung von Herz-Kreislauf-Erkrankungen, Hypertonie, von thromboembolischen Erkrankungen und Ischämien, sexueller Dysfunktion oder Entzündungen sowie zur Behandlung von Erkrankungen des Zentralnervensystems.
(EN)The invention relates to novel pyrazolopyridine derivatives of formula (I), wherein R1 represents (a) or (b) and n represents 1 or 2 and R2 represents H NH2. The invention also relates to salts, isomers and hydrates thereof as stimulators for soluble guanylate cyclase and to their use as agents in the treatment of cardiovascular diseases, hypertonicity, thrombo-embolic diseases and ischemia, sexual dysfunction or inflammations and for the treatment of diseases of the central nervous system.
(FR)La présente invention concerne de nouveaux dérivés de pyrazolopyridine de formule (I), dans laquelle R1 représente (a) ou (b) et n est égal à 1 ou à 2 et R2 représente H ou NH2, ainsi que des sels, des isomères et des hydrates de ceux-ci, ces composés stimulant la guanylate-cyclase soluble. L'invention concerne par ailleurs l'utilisation de ces composés pour traiter des maladies cardio-vasculaires, l'hypertonie, des maladies thromboemboliques et des ischémies, une dysfonction sexuelle ou des inflammations, ainsi que des maladies du système nerveux central.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)