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1. (WO2003004473) NOVEL BUTADIENE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004473    International Application No.:    PCT/JP2002/006047
Publication Date: 16.01.2003 International Filing Date: 18.06.2002
Chapter 2 Demand Filed:    18.06.2002    
IPC:
C07C 63/66 (2006.01), C07C 69/76 (2006.01), C07C 69/94 (2006.01), C07D 213/75 (2006.01)
Applicants: TANABE SEIYAKU CO., LTD. [JP/JP]; 2-10, Dosho-machi 3-chome, Chuo-ku, Osaka-shi, Osaka 541-8505 (JP) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
OHTANI, Akio [JP/JP]; (JP) (For US Only).
OGIKU, Tsuyoshi [JP/JP]; (JP) (For US Only).
YAMADA, Yasuhiro [JP/JP]; (JP) (For US Only)
Inventors: OHTANI, Akio; (JP).
OGIKU, Tsuyoshi; (JP).
YAMADA, Yasuhiro; (JP)
Agent: AOYAMA, Tamotsu; Aoyama & Partners, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 540-0001 (JP)
Priority Data:
2001-201686 03.07.2001 JP
Title (EN) NOVEL BUTADIENE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF
(FR) NOUVEAUX DERIVES DE BUTADIENE, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES POUR LEUR SYNTHESE
Abstract: front page image
(EN)Butadiene derivatives represented by the general formula [I] and having excellent PAI−1 inhibitory activity and so on, or pharmacologically acceptable salts thereof; a process for preparing the derivatives or the salts; and intermediates for the synthesis of the same: [I] wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl; R3 is lower alkoxy; R4 is hydrogen or lower alkyl; and R5 is lower alkyl.
(FR)L'invention concerne des dérivés de butadiène représentés par la formule générale [I] suivante, et présentant, notamment, une excellente activité d'inhibition de PAI-1, ou leurs sels pharmaceutiquement acceptables. Elle concerne un procédé de préparation de ces dérivés ou de ces sels; ainsi que les intermédiaires pour leur synthèse. R1 représente hydrogène ou alkyle inférieur; R2 alkyle inférieur; R3 alcoxy inférieur; R4 hydrogène ou alkyle inférieur; et R5 alkyle inférieur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)