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1. (WO2003004470) CRYSTALLINE FORMS OF 'R-(R*,R*)!-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-'PHENYLAMINO)CARBONYL!-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004470    International Application No.:    PCT/IB2002/001796
Publication Date: 16.01.2003 International Filing Date: 21.05.2002
Chapter 2 Demand Filed:    17.07.2002    
IPC:
C07D 207/34 (2006.01)
Applicants: WARNER-LAMBERT COMPANY LLC [US/US]; 201 Tabor Road, Morris Plains, NJ 07950 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
BYRN, Stephen, Robert [US/US]; (US) (For US Only).
COATES, David, Andrew [US/US]; (US) (For US Only).
GUSHURST, Karen, Sue [US/US]; (US) (For US Only).
MORRISON, Henry, Grant, II [US/US]; (US) (For US Only).
PARK, Aeri [KR/US]; (US) (For US Only).
VLAHOVA, Petinka Ivanova [BG/US]; (US) (For US Only).
LI, Zheng, Jane [US/US]; (US) (For US Only).
KRZYZANIAK, Joseph, Francis [US/US]; (US) (For US Only)
Inventors: BYRN, Stephen, Robert; (US).
COATES, David, Andrew; (US).
GUSHURST, Karen, Sue; (US).
MORRISON, Henry, Grant, II; (US).
PARK, Aeri; (US).
VLAHOVA, Petinka Ivanova; (US).
LI, Zheng, Jane; (US).
KRZYZANIAK, Joseph, Francis; (US)
Agent: LUMB, J., Trevor; Pfizer Inc., 201 Tabor Road, Morris Plains, NJ 07950 (US)
Priority Data:
60/302,049 29.06.2001 US
Title (EN) CRYSTALLINE FORMS OF 'R-(R*,R*)!-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-'PHENYLAMINO)CARBONYL!-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
(FR) FORMES CRISTALLINES DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-BETA,DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE)
Abstract: front page image
(EN)Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-$g(b), Δ;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
(FR)L'invention concerne des nouvelles formes cristallines de sel hémicalcique d'acide [R-(R*,R*)]-2-(4-fluorophényl)-$g(b),$g(d)-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque (atorvastatine), appelées Forme V, Forme VI, Forme VII, Forme VIII, Forme IX, Forme X, Forme XI, Forme XII, Forme XIII, Forme XIV, Forme XV, Forme XVI, Forme XVII, Forme XVIII et Forme XIX. Ces formes sont caractérisées par leur diffraction des rayons X sur poudre, leur NMR en phase solide et/ou leur spectroscopie Raman. L'invention concerne également des procédés de préparation et une composition pharmaceutique de ces formes, lesquelles sont utiles comme agents destinés à traiter l'hyperlipidémie, l'hypercholestérolémie, l'ostéoporose et la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)