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1. (WO2003004450) PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES ESPECIALLY 7-AMINO 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004450    International Application No.:    PCT/EP2002/007307
Publication Date: 16.01.2003 International Filing Date: 02.07.2002
Chapter 2 Demand Filed:    20.12.2002    
IPC:
C07C 69/67 (2006.01), C07C 69/716 (2006.01), C07C 69/732 (2006.01), C07C 69/738 (2006.01), C07C 227/32 (2006.01), C07C 229/22 (2006.01), C07C 235/06 (2006.01), C07C 235/74 (2006.01), C12P 7/62 (2006.01)
Applicants: CIBA SPECIALTY CHEMICALS HOLDING INC. [CH/CH]; Klybeckstrasse 141, CH-4057 Basel (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
ÖHRLEIN, Reinhold [DE/DE]; (DE) (For US Only).
BAISCH, Gabriele [DE/DE]; (DE) (For US Only).
END, Nicole [CH/CH]; (CH) (For US Only).
BURKHARDT, Stephan [CH/CH]; (CH) (For US Only).
STUDER, Martin [CH/CH]; (CH) (For US Only)
Inventors: ÖHRLEIN, Reinhold; (DE).
BAISCH, Gabriele; (DE).
END, Nicole; (CH).
BURKHARDT, Stephan; (CH).
STUDER, Martin; (CH)
Common
Representative:
CIBA SPECIALTY CHEMICALS HOLDING INC.; Patentabteilung, Klybeckstrasse 141, CH-4057 Basel (CH)
Priority Data:
01810670.8 06.07.2001 EP
Title (EN) PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES ESPECIALLY 7-AMINO 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, AND INTERMEDIATES THEREOF
(FR) PREPARATION D'INTERMEDIAIRES CONVENANT BIEN POUR LA SYNTHESE DE DERIVES DE STATINE, EN PARTICULIER DE DERIVES D'ACIDE 7-AMINO 3,5-DIHYDROXY HEPTANOIQUE ET DE DERIVES DE CET ACIDE
Abstract: front page image
(EN)The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.
(FR)Cette invention concerne des procédés de synthèse pour la préparation de dérivés de statine, qui font intervenir un intermédiaire clé de formule (I), dans laquelle X est halogène, acyloxy, hydrocarbyloxy activé, hydrocarbylthio activé ou N(CH3)OCH3, Ra est un groupe protecteur hydroxy, et Rb est un groupe protecteur carboxy. L'invention concerne également, comme pour le composé de formule (I), d'autres intermédiaires ainsi que leur procédés de préparation par acylation Friedel-Crafts.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)