Processing

Please wait...

Settings

Settings

Goto Application

1. WO2003004142 - PROCESS FOR THE PRODUCTION OF MICRO AND/OR NANO PARTICLES

Publication Number WO/2003/004142
Publication Date 16.01.2003
International Application No. PCT/IB2001/001780
International Filing Date 27.09.2001
Chapter 2 Demand Filed 29.04.2002
IPC
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
B01J 2/04 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials, in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
CPC
A61K 9/1688
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1688resulting in pure drug agglomerate optionally containing up to 5% of excipient
A61K 9/5192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5192Processes
B01J 2/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials ; , e.g. fertilisers; in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
Applicants
  • MICRO & NANO MATERIALS SAGL [CH]/[CH] (AT, AU, BE, CA, CH, CN, CY, DE, DK, ES, FI, FR, GB, GR, IE, IL, IT, JP, LU, MC, NL, PT, SE, SG, TR)
  • REVERCHON, Ernesto [IT]/[IT] (UsOnly)
Inventors
  • REVERCHON, Ernesto
Priority Data
1209/0102.07.2001CH
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PRODUCTION OF MICRO AND/OR NANO PARTICLES
(FR) PROCEDE DE PRODUCTION DE MICROPARTICULES ET/OU NANOPARTICULES
Abstract
(EN) A process and an apparatus are proposed to perform the supercritical assisted atomization of nano and/or micro metric powders. It is possible to use liquid solvent at process conditions in which they show a low solubility in carbon dioxide. Atomization is obtained by solubilizing pressurized carbon dioxide (compressed, liquid, supercritical) in a solution formed by the solid to be micronized and the liquid solvent, solubilizing carbon dioxide up to near equilibrium conditions and then atomizing the solution down to near atmospheric conditions through a thin wall injector, to produce very small droplet of micronic and sub-micronic dimensions. The subsequent evaporation of the droplets produces particles with diameters ranging between 0.02 and 10 micron.
(FR) L'invention porte sur un procédé et sur un appareil destinés à effectuer une atomisation assistée supercritique de poudres nanométriques et/ou micrométriques. Il est possible d'utiliser un solvant liquide dans des conditions de traitement où l'on a une faible solubilité du dioxyde de carbone. Pour réaliser l'atomisation, on solubilise le dioxyde de carbone sous pression (comprimé, liquide, supercritique) dans une solution formée par le solide à microniser et le solvant liquide, on solubilise le dioxyde de carbone jusqu'à atteindre des conditions d'équilibre proche et on atomise ensuite la solution de façon à descendre jusqu'à des conditions atmosphériques proches au moyen d'un injecteur à paroi mince de façon à générer de très petites gouttelettes de dimensions microniques et submicroniques. L'évaporation ultérieure des gouttelettes produit des particules ayant des diamètres compris entre 0,02 et 10 microns.
Latest bibliographic data on file with the International Bureau