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1. (WO2003004091) AROMATIC SULFENATES FOR TYPE I PHOTOTHERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004091    International Application No.:    PCT/US2002/019185
Publication Date: 16.01.2003 International Filing Date: 18.06.2002
Chapter 2 Demand Filed:    27.01.2003    
IPC:
A61K 41/00 (2006.01)
Applicants: MALLINCKRODT INC. [US/US]; 675 McDonnell Boulevard, P.O. Box 5840, St. Louis, MO 63134 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
RAJAGOPALAN, Raghavan [US/US]; (US) (For US Only).
CANTRELL, Gary, L. [US/US]; (US) (For US Only).
ACHILEFU, Samuel, I. [NG/US]; (US) (For US Only).
BUGAJ, Joseph, E. [US/US]; (US) (For US Only).
DORSHOW, Richard, B. [US/US]; (US) (For US Only)
Inventors: RAJAGOPALAN, Raghavan; (US).
CANTRELL, Gary, L.; (US).
ACHILEFU, Samuel, I.; (US).
BUGAJ, Joseph, E.; (US).
DORSHOW, Richard, B.; (US)
Agent: BOONE, Jeffrey, S.; Mallinckrodt Inc., 675 McDonnell Boulevard, P.O. Box 5840, St. Louis, MO 63134 (US)
Priority Data:
09/898,887 03.07.2001 US
Title (EN) AROMATIC SULFENATES FOR TYPE I PHOTOTHERAPY
(FR) SULFENATES AROMATIQUES POUR PHOTOTHERAPIE DE TYPE 1
Abstract: front page image
(EN)The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photofragmentation of the sulfenate moiety, with the tissue of interest.
(FR)La présente invention se rapporte à de nouveaux dérivés sulfénates et à leurs bioconjugués destinés à la photothérapie de tumeurs et d'autres lésions. Les sulfénates de la présente invention sont conçus pour absorber le rayonnement ultraviolet de faible énergie, le rayonnement visible ou le rayonnement dans le proche infrarouge NIR du spectre électromagnétique. L'effet photothérapeutique est le résultat de l'interaction directe, avec le tissu d'intérêt, des radicaux libres qui sont l'intermédiaire de réaction produit lors de la photofragmentation de la fraction sulfénate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)