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Machine translation
1. (WO2003004031) PARENTERAL ADMINISTRATION OF 6-HYDROXY-OXYMORPHONE FOR USE AS AN ANALGESIC
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004031    International Application No.:    PCT/US2002/021398
Publication Date: 16.01.2003 International Filing Date: 03.07.2002
Chapter 2 Demand Filed:    04.02.2003    
IPC:
A61K 9/20 (2006.01), A61K 31/485 (2006.01)
Applicants: ENDO PHARMACEUTICALS, INC. [US/US]; 100 Painters Drive, Chadds Ford, PA 19317 (US).
KAO, Huai-Hung [US/US]; (US) (For US Only).
SMITH-CARLISS, Richard [US/US]; (US) (For US Only).
MCCALL, Troy [US/US]; (US) (For US Only).
LEE, David [GB/US]; (US) (For US Only)
Inventors: KAO, Huai-Hung; (US).
SMITH-CARLISS, Richard; (US).
MCCALL, Troy; (US).
LEE, David; (US)
Agent: DONATIELLO, Guy, T.; Schnader Harrison Segal & Lewis LLP, 1600 Market Street, Suite 3600, Philadelphia, PA 19103 (US)
Priority Data:
60/303,357 06.07.2001 US
60/329,432 15.10.2001 US
60/329,445 15.10.2001 US
60/329,444 15.10.2001 US
Title (EN) PARENTERAL ADMINISTRATION OF 6-HYDROXY-OXYMORPHONE FOR USE AS AN ANALGESIC
(FR) ADMINISTRATION PARENTERALE DE 6-HYDROXY-OXYMORPHONE DESTINEE A ETRE UTILISEE EN TANT QU'ANALGESIQUE
Abstract: front page image
(EN)In a method of treating pain a patient is administered a pharmaceutical composition of 6-hydroxy oxymorphone in an amount sufficient to induce analgesia. In one embodiment,the pharmaceutical composition is administered parenterally, preferably by injection and intravenous drip. To achieve the desired analgesic effect, blood plasma levels of 6-hydroxy oxymorphone are raised to at least approximately 0.05 ng/mL during treatment. Administration of compositions containing 6-hidroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia is also contemplated.
(FR)Dans une méthode de traitement de la douleur, une composition pharmaceutique de 6-hydroxy oxymorphone est administrée à un patient en une dose suffisante pour induire une analgésie. Dans un mode de réalisation, la composition pharmaceutique est administrée par voie parentérale, de préférence par injection et par goutte-à-goutte intraveineux. Pour obtenir l'effet analgésique voulu, les niveaux de 6-hydroxy oxymorphone dans le plasma sanguin sont élevés jusqu'à au moins approximativement 0,05 ng/ML. Idéalement, les niveaux de 6-hydroxy oxymorphone dans le plasma sanguin s'établissent au moins à 0,075 ng/ML pendant le traitement. Est également prévue l'administration de compositions contenant la 6-hydroxy oxymorphone, ainsi qu'un ou plusieurs supports, diluants, et excipients en une dose suffisante pour induire une analgésie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)