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Machine translation
1. (WO2003004020) HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/004020    International Application No.:    PCT/EP2002/007215
Publication Date: 16.01.2003 International Filing Date: 29.06.2002
Chapter 2 Demand Filed:    31.01.2003    
IPC:
A61K 31/4025 (2006.01), A61K 31/4178 (2006.01), A61K 31/427 (2006.01), C07D 207/34 (2006.01), C07D 213/82 (2006.01), C07D 233/90 (2006.01), C07D 277/46 (2006.01), C07D 277/56 (2006.01), C07D 333/38 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 403/06 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 491/10 (2006.01)
Applicants: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Strasse 173, 55216 Ingelheim am Rhein (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW only).
PRIEPKE, Henning [DE/DE]; (DE) (For US Only).
HAUEL, Norbert [DE/DE]; (DE) (For US Only).
DAHMANN, Georg [DE/DE]; (DE) (For US Only).
THOMAS, Leo [DE/DE]; (DE) (For US Only).
MARK, Michael [DE/DE]; (DE) (For US Only)
Inventors: PRIEPKE, Henning; (DE).
HAUEL, Norbert; (DE).
DAHMANN, Georg; (DE).
THOMAS, Leo; (DE).
MARK, Michael; (DE)
Common
Representative:
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; Binger Strasse 173, 55216 Ingelheim am Rhein (DE)
Priority Data:
101 32 686.6 05.07.2001 DE
Title (DE) HETEROARYLCARBONSÄUREAMIDE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS INHIBITOREN DES MIKROSMALEN TRIGLYCERID-TRANSFERPROTEINS (MTP)
(EN) HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP)
(FR) AMIDES D'ACIDE HETEROARYLCARBOXYLIQUE, LEUR PRODUCTION ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE MICROSOMALE DE TRANSFERT DES TRIGLYCERIDES (MTP)
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft Heteroarylcarbonsäureamide der allgemeinen Formel (I), in der Aa, Ra, X1 bis X4, Het und R5 bis R7 wie im Anspruch 1 definiert sind, deren Isomere und deren Salze, insbesondere deren physiologisch verträgliche Salze, welche wertvolle Inhibitoren des mikrosomalen Triglyzerid-Transferproteins (MTP) darstellen, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie deren Herstellung.
(EN)The invention relates to heteroaryl carboxylic acid amides of general formula (I) wherein Aa, Ra, X1 to X4, Het and R5 to R7 are as defined in patent claim 1, and the isomers and salts of the same, especially the physiologically compatible salts thereof, representing valuable inhibitors of the microsomal triglyceride transfer protein (MTP). The invention also relates to pharmaceuticals containing said compounds, the use thereof and the production of the same.
(FR)La présente invention concerne des amides d'acide hétéroarylcarboxylique de formule générale (I), dans laquelle Aa, Ra, X1 à X4, Het et R5 à R7 sont tels que définis dans la revendication 1, des isomères de ceux-ci et des sels de ceux-ci, notamment des sels de ceux-ci compatibles d'un point de vue physiologique, qui constituent de précieux inhibiteurs de la protéine microsomale de transfert des triglycérides (MTP). La présente invention concerne également des médicaments renfermant ces composés, ainsi que leur utilisation et leur production.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)