WO2003003007 METHODS AND COMPOSITIONS USEFUL FOR THE PREDICTION OF BLOOD-BRAIN BARRIER PERMEATION

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Publication Number WO/2003/003007

Publication Date 09.01.2003

International Application No. PCT/US2002/019736

International Filing Date 20.06.2002

Chapter 2 Demand Filed 15.01.2003

IPC

CPC

Applicants

WYETH [US]/[US]

Inventors

DI, Li
KERNS, Edward, Harvel

Agents

CALNAN, William, H.
WILEMAN, David, F.

Priority Data

60/302,085

29.06.2001

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) METHODS AND COMPOSITIONS USEFUL FOR THE PREDICTION OF BLOOD-BRAIN BARRIER PERMEATION

(FR) METHODES ET COMPOSITIONS UTILES POUR PREDIRE LA PERMEABILITE DE LA BARRIERE HEMATO-ENCEPHALIQUE

Abstract

(EN) The present invention provides a method for the $i(in vitro) determination of the ability of a compound or a mixture of compounds to permeate the blood-brain barrier and a membrane composition useful therefor.

(FR) La présente invention concerne une méthode qui permet de déterminer $i(in vitro) la capacité d'un composé ou d'un mélange de composés à traverser la barrière hémato-encéphalique et une composition de membrane utile correspondante.

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48	Biological material, e.g. blood, urine; Haemocytometers
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92	involving lipids, e.g. cholesterol

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48	Biological material, e.g. blood, urine; Haemocytometers
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92	involving lipids, e.g. cholesterol

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92	involving lipids, e.g. cholesterol ; , lipoproteins, or their receptors

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92	involving lipids, e.g. cholesterol ; , lipoproteins, or their receptors

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1. WO2003003007 - METHODS AND COMPOSITIONS USEFUL FOR THE PREDICTION OF BLOOD-BRAIN BARRIER PERMEATION