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Machine translation
1. (WO2003002565) 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE N THE TREATMENT OF PROLIFERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/002565    International Application No.:    PCT/GB2002/002962
Publication Date: 09.01.2003 International Filing Date: 27.06.2002
Chapter 2 Demand Filed:    24.01.2003    
IPC:
C07D 473/16 (2006.01)
Applicants: CYCLACEL LIMITED [GB/GB]; 12 St. James's Square, London SW1Y 4RB (GB) (For All Designated States Except US).
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Sardinia House, Sardinia Street, London WC2A 3NL (GB) (For All Designated States Except US).
FISCHER, Peter, M. [CH/GB]; (GB) (For US Only).
JARMAN, Mike [GB/GB]; (GB) (For US Only).
MCDONALD, Edward [GB/GB]; (GB) (For US Only).
NUTLEY, Bernard [GB/GB]; (GB) (For US Only).
RAYNAUD, Florence [FR/GB]; (GB) (For US Only).
WILSON, Stuart [GB/GB]; (GB) (For US Only).
WORKMAN, Paul [GB/GB]; (GB) (For US Only)
Inventors: FISCHER, Peter, M.; (GB).
JARMAN, Mike; (GB).
MCDONALD, Edward; (GB).
NUTLEY, Bernard; (GB).
RAYNAUD, Florence; (GB).
WILSON, Stuart; (GB).
WORKMAN, Paul; (GB)
Agent: NACHSHEN, Neil; D. Young & Co., 21 New Fetter Lane, London EC4A 1DA (GB)
Priority Data:
0115713.0 27.06.2001 GB
0120333.0 21.08.2001 GB
Title (EN) 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE N THE TREATMENT OF PROLIFERATIVE DISORDERS
(FR) DERIVES DE PURINE 2,6,9-SUBSTITUES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES PROLIFERANTES
Abstract: front page image
(EN)The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 3-hydroxypiperidin-1-yl, or NHCH(R4)CH(R3) OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylarnino, 3,4-dimethoxybenzylarnino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and/or viral disorders.
(FR)L'invention concerne des composés représentés par la formule I ou un sel pharmaceutiquement acceptable de ces composés. Dans cette formule, R2 représente 3-hydroxypiperidin-1-yle ou NHCH(R4)CH(R3) OH, où R3 représente hydrogène ou méthyle et R4 représente méthyle, éthyle ou isopropyle ; R6 représente 3-nitrophénylamino, 3,4-diméthoxybenzylamino, pyrid-2-yl-méthylamino, pyrid-4-yl-méthylamino ou indan-5-amino; R9 représente isopropyle ou cyclopentanyle. Dans un autre aspect, l'invention concerne des compositions pharmaceutiques contenant lesdits composés ainsi que l'utilisation de ces compositions dans le traitement de maladies proliférantes et/ou virales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)