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1. (WO2003002561) N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/002561 International Application No.: PCT/EP2002/007009
Publication Date: 09.01.2003 International Filing Date: 25.06.2002
Chapter 2 Demand Filed: 22.01.2003
IPC:
C07D 401/06 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/14 (2006.01) ,C07D 405/06 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 417/04 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/04 (2006.01) ,C07D 491/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants: BRANCH, Clive, Leslie[GB/GB]; GB (UsOnly)
CHAN, Wai, Ngor[GB/GB]; GB (UsOnly)
JOHNS, Amanda[GB/GB]; GB (UsOnly)
JOHNSON, Christopher, Norbert[GB/GB]; GB (UsOnly)
NASH, David, John[GB/GB]; GB (UsOnly)
NOVELLI, Riccardo[IT/GB]; GB (UsOnly)
PILLEUX, Jean-Pierre[FR/GB]; GB (UsOnly)
PORTER, Roderick, Alan[GB/GB]; GB (UsOnly)
STEAD, Rachel, Elizabeth, Anne[GB/GB]; GB (UsOnly)
STEMP, Geoffrey[GB/GB]; GB (UsOnly)
SMITHKLINE BEECHAM P.L.C.[GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS, GB (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW)
Inventors: BRANCH, Clive, Leslie; GB
CHAN, Wai, Ngor; GB
JOHNS, Amanda; GB
JOHNSON, Christopher, Norbert; GB
NASH, David, John; GB
NOVELLI, Riccardo; GB
PILLEUX, Jean-Pierre; GB
PORTER, Roderick, Alan; GB
STEAD, Rachel, Elizabeth, Anne; GB
STEMP, Geoffrey; GB
Agent: HOCKLEY, Siân, Catherine; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford, Middlesex TW8 9GS, GB
Priority Data:
0115863.328.06.2001GB
0130342.919.12.2001GB
Title (EN) N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
(FR) DERIVES D'AMINE CYCLIQUES N-AROYLE UTILISES COMME ANTAGONISTES DU RECEPTEUR DE L'OREXINE
Abstract:
(EN) This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen , NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
(FR) L'invention concerne des dérivés d'amine cycliques N-aroyle correspondant à la formule (I), dans laquelle: X représente une liaison, oxygène, NR3 ou un groupe (CH2)n9, où n vaut 1, 2 ou 3; Y représente CH2, CO, CH(OH), ou bien CH2CH(OH); Het représente un groupe hétéroaryle bicyclique éventuellement substitué, contenant jusqu'à 4 hétéroatomes sélectionnés parmi N, O et S; Ar2 représente un groupe phényle éventuellement substitué ou un groupe hétérocyclyle à 5 ou 6 éléments, contenant jusqu'à 3 hétéroatomes sélectionnés parmi N, O et S. L'invention concerne également l'utilisation de ces dérivés en tant que produits pharmaceutiques, spécifiquement en tant qu'antagonistes du récepteur de l'oréxine.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)