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1. (WO2003002544) N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/002544    International Application No.:    PCT/US2002/020341
Publication Date: 09.01.2003 International Filing Date: 26.06.2002
Chapter 2 Demand Filed:    21.01.2003    
IPC:
C07D 213/85 (2006.01), C07D 239/48 (2006.01), C07D 239/50 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000, Route 206 and Provinceline Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
PHARMACOPEIA, INC. [US/US]; 3000 Eastpark Boulevard, Cranbury, NJ 08512 (US) (For All Designated States Except US).
AHMED, Gulzar [PK/US]; (US) (For US Only).
METZGER, Axel [DE/US]; (US) (For US Only).
WROBLESKI, Stephen, T. [US/US]; (US) (For US Only).
HENDERSON, Ian [GB/US]; (US) (For US Only).
WEN, James [US/US]; (US) (For US Only).
DILLER, David, J. [US/US]; (US) (For US Only).
LEFTHERIS, Katerina [US/US]; (US) (For US Only)
Inventors: AHMED, Gulzar; (US).
METZGER, Axel; (US).
WROBLESKI, Stephen, T.; (US).
HENDERSON, Ian; (US).
WEN, James; (US).
DILLER, David, J.; (US).
LEFTHERIS, Katerina; (US)
Agent: O'BRIEN, Maureen; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/301,020 26.06.2001 US
Title (EN) N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION
(FR) INHIBITEURS N-HETEROCYCLIQUES D'EXPRESSION TNF-ALPHA
Abstract: front page image
(EN)N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-$g(a) expression utilizing compounds of the present invention are also disclosed.
(FR)L'invention concerne des composés N-hétérocycliques qui bloquent la production de cytokine par l'intermédiaire de l'inhibition de la kinase p38. Dans un mode de réalisation, des composés de cette invention sont représentés par la formule (I). Ladite invention a également trait à des méthodes d'élaboration de compositions pharmaceutiques et à des méthodes de traitement de troubles liés à l'activité inadéquate de la kinase p38 ou à l'expression TNF-$g(a), au moyen des composés susmentionnés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)