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1. (WO2003002542) N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/002542 International Application No.: PCT/US2002/020212
Publication Date: 09.01.2003 International Filing Date: 25.06.2002
Chapter 2 Demand Filed: 22.01.2003
IPC:
C07D 251/52 (2006.01) ,C07D 251/54 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 521/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
251
Heterocyclic compounds containing 1,3,5-triazine rings
02
not condensed with other rings
12
having three double bonds between ring members or between ring members and non-ring members
26
with only hetero atoms directly attached to ring carbon atoms
40
Nitrogen atoms
48
Two nitrogen atoms
52
with an oxygen or sulfur atom attached to the third ring carbon atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
251
Heterocyclic compounds containing 1,3,5-triazine rings
02
not condensed with other rings
12
having three double bonds between ring members or between ring members and non-ring members
26
with only hetero atoms directly attached to ring carbon atoms
40
Nitrogen atoms
54
Three nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
Applicants: MORIARTY, Kevin, J.[US/US]; US (UsOnly)
SHIMSHOCK, Yvonne[US/US]; US (UsOnly)
AHMED, Gulzar[PK/US]; US (UsOnly)
WU, Junjun[CN/US]; US (UsOnly)
WEN, James[CN/US]; US (UsOnly)
LI, Wei[CN/US]; US (UsOnly)
ERICKSON, Shawn, D.[US/US]; US (UsOnly)
LETOURNEAU, Jeffrey, J.[US/US]; US (UsOnly)
MCDONALD, Edward[GB/GB]; GB (UsOnly)
LEFTHERIS, Katerina[US/US]; US (UsOnly)
WROBLESKI, Stephen, T.[US/US]; US (UsOnly)
HUSSAIN, Zahid[PK/US]; US (UsOnly)
HENDERSON, Ian[GB/US]; US (UsOnly)
METZGER, Axel[DE/US]; US (UsOnly)
BALDWIN, John, J.[US/US]; US (UsOnly)
DYCKMAN, Alaric[US/US]; US (UsOnly)
BRISTOL-MYERS SQUIBB COMPANY[US/US]; P. O. Box 4000 Route 206 and Provinceline Road Princeton, NJ 08543-4000, US (AllExceptUS)
PHARMACOPEIA, INC.[US/US]; 3000 Eastpark Boulevard Cranbury, NJ 08512, US (AllExceptUS)
Inventors: MORIARTY, Kevin, J.; US
SHIMSHOCK, Yvonne; US
AHMED, Gulzar; US
WU, Junjun; US
WEN, James; US
LI, Wei; US
ERICKSON, Shawn, D.; US
LETOURNEAU, Jeffrey, J.; US
MCDONALD, Edward; GB
LEFTHERIS, Katerina; US
WROBLESKI, Stephen, T.; US
HUSSAIN, Zahid; US
HENDERSON, Ian; US
METZGER, Axel; US
BALDWIN, John, J.; US
DYCKMAN, Alaric; US
Agent: O'BRIEN, Maureen ; Bristol-Myers Squibb Company P.O. Box 4000 Princeton, NJ 08543-4000, US
Priority Data:
09/891,75026.06.2001US
Title (EN) N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION
(FR) INHIBITEURS N-HETEROCYCLIQUES DE L'EXPRESSION DE TNF-ALPHA
Abstract:
(EN) N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-a expression utilizing compounds of the present invention are also disclosed.
(FR) L'invention concerne des composés N-hétérocycliques bloquant la production de cytokines par inhibition de la kinase p38. Dans un mode de réalisation, les composés de la présente invention sont représentés par la formule (I). L'invention concerne également des méthodes de production correspondantes, des compositions pharmaceutiques et des méthodes de traitement d'états pathologiques associés à une activité kinase p38 ou une expression TNF-$g(a) inappropriée au moyen des composés de la présente invention.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)