WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2003001981) METHOD OF PROMOTING ENGRAFTMENT OF A DONOR TRANSPLANT IN A RECIPIENT HOST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/001981    International Application No.:    PCT/US2002/020550
Publication Date: 09.01.2003 International Filing Date: 28.06.2002
Chapter 2 Demand Filed:    29.01.2003    
IPC:
A61K 35/14 (2006.01), A61K 39/00 (2006.01), C07K 16/28 (2006.01), C12N 5/0783 (2010.01), A61K 35/12 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATE OF AMERICA as represent by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325, Rockville, MD20852 (US) (For All Designated States Except US).
MURPHY, William, J. [US/US]; (US) (For US Only).
KOH, Crystal [US/US]; (US) (For US Only).
BENNETT, Michael, D. [US/US]; (US) (For US Only).
ROMAGNE, Francois [FR/FR]; (FR) (For US Only)
Inventors: MURPHY, William, J.; (US).
KOH, Crystal; (US).
BENNETT, Michael, D.; (US).
ROMAGNE, Francois; (FR)
Agent: LARCHER, Carol; Leydig, Voit & Mayer, Ltd., Suite 4900, Two Prudential Plaza, 180 North Stetson, Chicago, IL 60601-6780 (US)
Priority Data:
60/302,258 29.06.2001 US
Title (EN) METHOD OF PROMOTING ENGRAFTMENT OF A DONOR TRANSPLANT IN A RECIPIENT HOST
(FR) METHODE FAVORISANT LA PRISE DE GREFFE D'UN GREFFON DE DONNEUR CHEZ UN RECEVEUR HOTE
Abstract: front page image
(EN)A method of promoting engraftment of a donor transplant in a recipient host, comprising adoptive transfer to the recipient host donor natural killer (NK) cells, which have been treated $i(ex vivo) to interfere with the ability of inhibitory receptors on the donor NK cells to interact with major histocompatibility complex molecules in the recipient host, simultaneously with, or sequentially to, in either order, the donor transplant, whereupon the engraftment of the donor transplant in the recipient host is promoted.
(FR)L'invention concerne une méthode favorisant la prise de greffe d'un greffon provenant d'un donneur chez un receveur hôte, cette méthode comprend le transfert adoptif de cellules NK du donneur hôte au receveur hôte. Lesdites cellules NK ont été traitées ex vivo de façon à perturber la capacité des récepteurs inhibiteurs sur les cellules NK du donneur, d'interagir avec des molécules du complexe majeur d'histocompatibilité chez le receveur hôte, simultanément ou séquentiellement au greffon du donneur, quel que soit l'ordre, après quoi la prise de greffe du greffon du donneur est favorisée chez le receveur hôte.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)