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1. (WO2003000714) COMPOSITIONS AND METHODS FOR PREVENTING PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/000714 International Application No.: PCT/US2002/020009
Publication Date: 03.01.2003 International Filing Date: 24.06.2002
IPC:
C07K 16/18 (2006.01)
Applicants: GHANBARI, Hossein, A.[US/US]; US (UsOnly)
GHANBARI, Kasra[US/US]; US (UsOnly)
PANACEA PHARMACEUTICALS, INC.[US/US]; 9700 Great Seneca Hwy. Rockville, MD 20850, US (AllExceptUS)
Inventors: GHANBARI, Hossein, A.; US
GHANBARI, Kasra; US
Agent: GOTTS, Lawrence, J. ; Shaw Pittman LLP 1650 Tysons Boulevard McLean, VA 22102-4859, US
Priority Data:
60/300,19022.06.2001US
Title (EN) COMPOSITIONS AND METHODS FOR PREVENTING PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASES
(FR) COMPOSITIONS ET PROCEDES POUR LA PREVENTION D'AGREGATION DE PROTEINES DANS DES MALADIES NEURODEGENERATIVES
Abstract:
(EN) Disclosed are methods for treating a disease that involves protein aggregation, including Alzheimer's, Parkinson's, prion diseases such as BSE and CJD, and Down's syndrome. The methods involve administering to a subject suspected of having the disease a very high affinity antibody fragment immunoreactive with the protein that is aggregating. Such treatment will have the effect of preventing, slowing, or halting the disease progression by inhibiting protein aggregation.
(FR) La présente invention concerne des procédés pour le traitement d'une maladie impliquant l'agrégation de protéines, dont la maladie d'Alzheimer, la maladie de Parkinson, les maladies à prion telles que l'encéphalopathie bovine spongiforme (ESB) et la maladie de la vache folle (CJD), et le syndrome de Down. Le procédé comporte l'administration à un sujet suspecté de souffrir de la maladie un fragment d'anticorps à très haute affinité immunoréactive avec la protéine qui produit l'agrégation. Un tel traitement aura pour effet la prévention, le ralentissement ou l'arrêt de la progression de la maladie par l'inhibition de l'agrégation des protéines.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)