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1. (WO2003000687) TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/000687 International Application No.: PCT/US2002/021110
Publication Date: 03.01.2003 International Filing Date: 18.06.2002
Chapter 2 Demand Filed: 09.01.2003
IPC:
C07D 417/12 (2006.01) ,C07D 417/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
Applicants: BILODEAU, Mark, T.[US/US]; US (UsOnly)
HARTMAN, George, D.[US/US]; US (UsOnly)
MERCK & CO., INC.[US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US (AllExceptUS)
Inventors: BILODEAU, Mark, T.; US
HARTMAN, George, D.; US
Agent: BROWN, Dianne; Merck & Co., Inc. PO BOX 2000 126 East Lincoln Avenue Rahway__NJ07065-0907, US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US
Priority Data:
60/300,24522.06.2001US
Title (EN) TYROSINE KINASE INHIBITORS
(FR) INHIBITEURS DE TYROSINE KINASE
Abstract:
(EN) The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals. A compound of Formula (I) wherein n is 0 or 1; X is C-H or N, provided X is C-H if n=1 and R1 is SO2-(C1-C6 alkyl) and provided that X is C-H if R1 is NH(C=O)NR3H; R1 is SO2-(C1-C6 alkyl), (C=O)NR3H, or NH(C=O)NR3H; R2 is OH OC1-C6 alkyl, C1-C6 alkyl, or halo; and R3 is C1-C6 alkyl.
(FR) L'invention concerne des composés inhibant, régulant et/ou modulant une transduction de signal de tyrosine kinase, des compositions contenant ces composés, et des méthodes utilisant ces composés afin de traiter des troubles et des maladies associés à la tyrosine kinase, tels que l'angiogénèse, le cancer, la croissance tumorale, l'athérosclérose, la dégénération maculaire liée à l'âge, la rétinopathie diabétique, les maladies inflammatoires, et analogues chez les mammifères. Un composé est représenté par la formule (I) dans laquelle n est égal à 0 ou 1; X représente C-H ou N, à condition que X représente C-H lorsque n=1 et que R1 représente SO2-(C1-C6 alkyl), et à condition que X représente C-H lorsque R1 représente NH(C=O)NR3H; R1 représente SO2-(C1-C6 alkyl), (C=O)NR3H, ou NH(C=O)NR3H; R2 représente H, OH, OC1-C6 alkyle, C1-C6 alkyle, ou halo; et R3 représente C1-C6 alkyle.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)