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1. (WO2003000675) SUBSTITUTED BENZOPYRAN DERIVATIVES AGAINST ARRHYTHMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/000675 International Application No.: PCT/JP2002/006012
Publication Date: 03.01.2003 International Filing Date: 17.06.2002
Chapter 2 Demand Filed: 28.11.2002
IPC:
C07D 311/68 (2006.01)
Applicants: OHARA, Yoshio[JP/JP]; JP (UsOnly)
OHRAI, Kazuhiko[JP/JP]; JP (UsOnly)
YANAGIHARA, Kazufumi[JP/JP]; JP (UsOnly)
SHIGETA, Yukihiro[JP/JP]; JP (UsOnly)
TSUKAGOSHI, Toru[JP/JP]; JP (UsOnly)
YAMASHITA, Toru[JP/JP]; JP (UsOnly)
NISSAN CHEMICAL INDUSTRIES, LTD.[JP/JP]; 7-1, Kandanishiki-cho 3-chome Chiyoda-ku, Tokyo 101-0054, JP (AllExceptUS)
Inventors: OHARA, Yoshio; JP
OHRAI, Kazuhiko; JP
YANAGIHARA, Kazufumi; JP
SHIGETA, Yukihiro; JP
TSUKAGOSHI, Toru; JP
YAMASHITA, Toru; JP
Agent: HANABUSA, Tsuneo ; c/o Hanabusa Patent Office Sin-ochanomizu Urban Trinity 2, Kandasurugadai 3-chome Chiyoda-ku, Tokyo 101-0062, JP
Priority Data:
2001-19059425.06.2001JP
Title (EN) SUBSTITUTED BENZOPYRAN DERIVATIVES AGAINST ARRHYTHMIA
(FR) DERIVES DE BENZOPYRANE SUBSTITUE CONTRE L'ARYTHMIE
Abstract: front page image
(EN) This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.
(FR) L'invention concerne des dérivés de benzopyrane de la formule (1) ou de la formule (2) suivantes, dans lesquelles R1 et R2 représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupe C1-6 alkyle, R3 représente un groupe hydroxyle ou un groupe C1-6 alkylcarbonyloxy, R4 représente un atome d'hydrogène ou C1-6 alkyle, R5 représente un groupe C1-6 alkyle substitué par un groupe C6-14 aryl ou un groupe hétéroaryle. R6 représente un groupe C1-6 alkyle, un groupe C1-6 alcoxy, un atome halogène, un groupe nitro, C(O)NH2, C(O)NHR8 ou C(O)NR8R9, ou un sel de ceux-ci pharmaceutiquement acceptables. Ces composés peuvent servir comme agent antiarythmique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)