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1. (WO2003000294) PHARMACEUTICAL COMPOSITIONS CONTAINING A SOLID DISPERSION OF A POORLY-SOLUBLE DRUG IN A MATRIX AND A SOLUBILITY-ENHANCING POLYMER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/000294 International Application No.: PCT/IB2002/001800
Publication Date: 03.01.2003 International Filing Date: 13.05.2002
Chapter 2 Demand Filed: 21.06.2002
IPC:
A61K 9/14 (2006.01)
Applicants: BABCOCK, Walter, Christian[US/US]; US (UsOnly)
CURATOLO, William, John[US/US]; US (UsOnly)
FRIESEN, Dwayne, Thomas[US/US]; US (UsOnly)
KETNER, Rodney, James[US/US]; US (UsOnly)
LO, Julian, Belknap[US/US]; US (UsOnly)
NIGHTINGALE, James, Alan, Schriver[US/US]; US (UsOnly)
SHANKER, Ravi, Mysore[US/US]; US (UsOnly)
WEST, James, Blair[US/US]; US (UsOnly)
PFIZER PRODUCTS INC.[US/US]; Eastern Point Road Groton, CT 06340, US (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW)
Inventors: BABCOCK, Walter, Christian; US
CURATOLO, William, John; US
FRIESEN, Dwayne, Thomas; US
KETNER, Rodney, James; US
LO, Julian, Belknap; US
NIGHTINGALE, James, Alan, Schriver; US
SHANKER, Ravi, Mysore; US
WEST, James, Blair; US
Agent: LUMB, J., Trevor; Pfizer Inc. 201 Tabor Road Morris Plains, NJ 07950, US
Priority Data:
60/300,26122.06.2001US
Title (EN) PHARMACEUTICAL COMPOSITIONS CONTAINING A SOLID DISPERSION OF A POORLY-SOLUBLE DRUG IN A MATRIX AND A SOLUBILITY-ENHANCING POLYMER
(FR) COMPOSITIONS PHARMACEUTIQUES CONTENANT UNE DISPERSION SOLIDE D'UN MEDICAMENT PEU SOLUBLE DANS UNE MATRICE ET D'UN POLYMERE AMELIORANT LA SOLUBILITE
Abstract:
(EN) A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
(FR) L'invention concerne des compositions pharmaceutiques contenant une dispersion solide composée d'un médicament peu soluble et d'une matrice combinée à un polymère améliorant la concentration. Au moins une partie majeure dudit médicament est amorphe dans la dispersion. Les compositions selon l'invention permettent d'améliorer la stabilité du médicament dans la dispersion et/ou la concentration du médicament dans un environnement d'utilisation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)